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Nanocomposites based on hydroxyapatite (HAP), including MoO3, HAP/MoO3, HAP/GO and HAP/MoO3/GO have been studied to be suggested for biological usage. The different compositions were investigated using FTIR, XRD, EDS, and XPS analysis. The tight relation between morphological features and composites' chemical ingredients was also studied. According to TEM micrographs, it was mentioned that the disappearance of well-defined grains after the combinations of HAP and MoO3, while graphene oxide (GO) caused a reduction in size and maintaining the particles' shape. The combination between HAP/MoO3 declines the roughness of both HAP and MoO3 individually, recording 27.5 nm, while HAP/GO and HAP/MoO3/GO exhibit in-between roughness average (Ra) value among its raw constituents with 34.7 and 33.5 nm, respectively. Furthermore, SEM micrographs and roughness results show how to tailing the proper features for the proposed application by changing the type and amount of additives into HAP. Thus, the composite (HAP/MoO3/GO) displays the uppermost cell viability compared with the rest compositions with 97.8 ± 3.0%. Additionally, this triple composite hits the peak germicidal behavior with 17.9 ± 1.2 and 16.5 ± 0.9 mm against both E.coli and S.aureus, respectively. [ABSTRACT FROM AUTHOR]

Nanocomposites offer the desired properties with multi-functionality behavior. Hydroxyapatite (HAP), cadmium selenide (CdSe), and graphene oxide (GO) were combined in mono, di, and tri phases compositions. The morphology, structure, and chemical composition were investigated for HAP, CdSe, HAP/CdSe, HAP/GO and HAP/CdSe/GO using X-ray diffraction (XRD), transmission electron microscope, scanning electron microscope (SEM), and X-ray photoelectron spectroscopy (XPS). XRD shows that the crystallite size increased from 28 nm to 37 nm. SEM analysis shows the roughness average (Ra) starts from 27.8 increases till 28.8 nm for HAP and HAP/CdSe/GO, while the average maximum height of the roughness (Rtm) starts from 214.2 to 212.7 nm. The existence of HAP, CdSe, and GO was confirmed with XPS, EDX, and FTIR. The polarization behavior was investigated and the corrosion current density (Icorr) of the ternary nanocomposite reached 3.7 µA/cm2, while potential corrosion reached around − 0.3 V. It was found that the release of Cd2+ and Ca2+ ions increased upon the time of exposure up to around 23± 3 and 132 ± 4 ppm, respectively. The cell viability of osteoblasts human cell line toward the ternary nanocomposite reached 95.1 ± 3%. The antibacterial activity was studied and it was found that the inhibition zone reached around 20.4 ± 1.1 and 21.4 ± 0.9 mm against E. coli and S. aureus, respectively. [ABSTRACT FROM AUTHOR]