1. Association of hepatosplenic schistosomiasis with HLA-DQB1*0201.
- Author
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Secor WE, del Corral H, dos Reis MG, Ramos EA, Zimon AE, Matos EP, Reis EA, do Carmo TM, Hirayama K, David RA, David JR, Harn DA Jr, Secor, W E, del Corral, H, dos Reis, M G, Ramos, E A, Zimon, A E, Matos, E P, Reis, E A, and do Carmo, T M
- Abstract
Major histocompatibility class II alleles of 351 persons living in an area endemic for Schistosoma mansoni in northeastern Brazil were characterized at three loci (DRB1, DQA1, and DQB1). Contingency analyses were used to compare allele frequencies with high egg excretion, proliferative response to schistosome soluble egg antigens (SEA), and occurrence of severe, biopsy-confirmed hepatosplenic disease. There were no associations of HLA-DR or DQ with egg excretion. Patients positive for DRB1*01, DQA1*0101, or DQB1*0501 were less likely to respond to SEA than was the overall study population. However, using stringent Bonferroni correction (multiplying P values by the number of alleles tested; P x 35), none of these associations with SEA responsiveness remained significant. Hepatosplenic disease was less likely in patients positive for DRB1*11 and was more likely in patients positive for DRB1*07 or DQB1*0201. However, only the DQB1*0201 association remained significant (odds ratio = 3.72; P < .005) following Bonferroni correction. [ABSTRACT FROM AUTHOR]
- Published
- 1996
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