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Your search keyword '"Koh, Andrew Y."' showing total 2 results
Start Over Author "Koh, Andrew Y." Journal journal of infectious diseases
2 results on '"Koh, Andrew Y."'

1. Analysis of acquisition of Pseudomonas aeruginosa gastrointestinal mucosal colonization and horizontal transmission in a murine model

Author

Kamei, Akinobu, Koh, Andrew Y., Gadjeva, Mihaela, Priebe, Gregory P., Lory, Stephen, and Pier, Gerald B.

Subjects
Disease transmission -- Models, Disease transmission -- Development and progression, Disease transmission -- Research, Pseudomonas aeruginosa -- Distribution, Pseudomonas aeruginosa -- Research, Gastrointestinal mucosa -- Physiological aspects, Gastrointestinal mucosa -- Research, Company distribution practices, Health
Published
2010

2. Collaboration Between Macrophages and Vaccine-Induced CD4+ T Cells Confers Protection Against Lethal Pseudomonas aeruginosa Pneumonia During Neutropenia.

Author

Kamei, Akinobu, Wu, Weihui, Traficante, David C., Koh, Andrew Y., Van Rooijen, Nico, Pier, Gerald B., and Priebe, Gregory P.

Subjects
MACROPHAGES, CD4 antigen, PSEUDOMONAS aeruginosa infections, T cells, NEUTROPENIA, PNEUMONIA, BACTERIAL vaccines, BACTERIAL disease prevention
Abstract

The usefulness of vaccine-based strategies to prevent lethal bacterial infection in a host with neutropenia is not well-defined. Here, we show in a neutropenic mouse model that immunity induced by mucosal vaccination with a live-attenuated Pseudomonas aeruginosa vaccine is protective against lethal P. aeruginosa pneumonia caused by both vaccine-homologous and vaccine-heterologous strains, whereas passive immunization confers only vaccine-homologous protection. Cells in the macrophage lineage served as crucial innate cellular effectors in the neutropenic host after active immunization. Vaccine efficacy was CD4+ T-cell dependent and associated with accumulation of macrophage-lineage cells in the alveolar space after infection, as well as with enhanced P. aeruginosa clearance from the lung. Adaptive CD4+ T cells produced granulocyte-macrophage colony-stimulating factor (GM-CSF) on restimulation in vitro, and local GM-CSF was critical for vaccine efficacy. Thus, collaboration between the innate and adaptive effectors induced by mucosal vaccination can overcome neutropenia and confer protection against lethal bacterial infection in the profoundly neutropenic host. [ABSTRACT FROM AUTHOR]

Published
2013
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