1. Persistent HIV Type 1 Seronegative Status Is Associated With Lower CD8+ T-Cell Activation.
- Author
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Kuebler PJ, Mehrotra ML, Shaw BI, Leadabrand KS, Milush JM, York VA, Defechereux P, Grant RM, Kallás EG, and Nixon DF
- Subjects
- ADP-ribosyl Cyclase 1 analysis, Adolescent, Adult, CD8-Positive T-Lymphocytes chemistry, HIV Infections virology, HIV-1 immunology, HLA-DR Antigens analysis, Humans, Male, Membrane Glycoproteins analysis, Young Adult, CD8-Positive T-Lymphocytes immunology, HIV Infections pathology, Lymphocyte Activation, T-Lymphocyte Subsets immunology
- Abstract
We leveraged data from the Preexposure Prophylaxis Initiative (iPrEx), a global trial of preexposure chemoprophylaxis against human immunodeficiency virus type 1 (HIV-1) infection, to compare T-cell activation between those who remained negative for HIV-1 and those who became infected during the trial. The frequency of CD38(+)HLA-DR(+) CD8(+) T cells was greater in those who seroconverted, relative to the frequency in those who remained uninfected (1.30% vs 0.82%, respectively; P = .005). This translated to an odds ratio of 4.26 (95% confidence interval, 1.54-11.78) for the association between CD8(+) T-cell activation and infection with HIV-1. T-cell activation may be a biomarker for elevated HIV-1 infection risk., (© The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.)
- Published
- 2016
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