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Your search keyword '"Dutra, Walderez O."' showing total 5 results
Start Over Author "Dutra, Walderez O." Journal journal of infectious diseases
5 results on '"Dutra, Walderez O."'

1. Interleukin 17 production among patients with American cutaneous leishmaniasis

Author

Bacellar, Olivia, Faria, Daniela, Nascimento, Marcia, Cardoso, Thiago M., Gollob, Kenneth J., Dutra, Walderez O., Scott, Phillip, and Carvalho, Edgar M.

Subjects
Leishmaniasis, Cutaneous -- Development and progression, Leishmaniasis, Cutaneous -- Physiological aspects, Leishmaniasis, Cutaneous -- Research, Interleukins -- Measurement, Interleukins -- Physiological aspects, Interleukins -- Research, Health
Published
2009

2. Helminthic infection down-regulates type 1 immune responses in human T cell lymphotropic virus type 1 (HTLV-1) carriers and is more prevalent in HTLV-1 carriers than in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis

Author

Porto, Aurelia F., Santos, Silvane B., Muniz, Andre L., Basilio, Vanessa, Rodrigues, Waldyr, Jr., Neva, Franklin A., Dutra, Walderez O., Gollob, Kenneth J., Jacobson, Steven, and Carvalho, Edgar M.

Subjects
Helminths -- Health aspects, Worms, Intestinal and parasitic -- Health aspects, HTLV-I (Virus) -- Physiological aspects, Immune response, Health
Published
2005

3. A Th2-Type Response Is Associated With Exuberant Lesions in Pregnant Women Infected With Leishmania braziliensis.

Author

Dutra, Walderez O, Barbosa, Daniela Faria, Souza, Paulo Eduardo Alencar de, Morgan, Daniel, Poetker, Shelene, Guimarães, Luiz Henrique, Bacelar, Olívia, Gollob, Kenneth J, Carvalho, Edgar M, and de Souza, Paulo Eduardo Alencar

Subjects
*LEISHMANIASIS, *PREGNANT women, *CYTOKINES, *NEUTROPHILS, *CD4 antigen, *INTERFERON gamma, *COMPARATIVE studies, *INTERFERONS, *INTERLEUKINS, *LEISHMANIA, *RESEARCH methodology, *MEDICAL cooperation, *RESEARCH, *SKIN, *T cells, *EVALUATION research
Abstract

Background: Cutaneous leishmaniasis (CL) is characterized by an exaggerated inflammatory response. During pregnancy there is a decreased inflammatory response, and we have shown that pregnant women with CL develop exuberant lesions.Methods: Cytokine production by peripheral blood mononuclear cells and the frequency of cells expressing cytokines in lesions from pregnant and nonpregnant women with CL were evaluated.Results: We observed that CL lesions from pregnant women displayed a more intense cellular infiltrate, associated with an increase in neutrophils and CD4+ cells. While no difference was observed regarding the number of interferon-gamma (IFN-γ)+ cells in lesions from pregnant compared to nonpregnant women with CL, interleukin-10 (IL-10) and IL-4 expression were approximately 3-times higher in lesions in pregnant women. Main sources of IL-4 and IL-10 were CD4+ and CD68+ cells, respectively. Expression of IL-4, but not IFN-γ or IL-10, was positively correlated with the intensity of inflammatory infiltrate in lesions from pregnant women.Conclusions: These results provide evidence of an IL-4-mediated pathology in Leishmania braziliensis-infected pregnant women. These differences in lesion pathogenesis in pregnant and nonpregnant women may open possibilities for new therapies for CL treatment during pregnancy, which are currently lacking. [ABSTRACT FROM AUTHOR]

Published
2019
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4. Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy

Author

Costa, Germano C., da Costa Rocha, Manoel Otavio, Moreira, Paula Rocha, Menezes, Cristiane Alves Silva, Silva, Micena R., Gollob, Kenneth J., and Dutra, Walderez O.

Subjects
Genetic polymorphisms -- Physiological aspects, Genetic polymorphisms -- Reports, Chagas' disease -- Development and progression, Chagas' disease -- Physiological aspects, Chagas' disease -- Reports, Cardiomyopathy -- Development and progression, Cardiomyopathy -- Physiological aspects, Cardiomyopathy -- Reports, Heart diseases -- Development and progression, Heart diseases -- Physiological aspects, Heart diseases -- Reports, Interleukin-10 -- Genetic aspects, Interleukin-10 -- Physiological aspects, Interleukin-10 -- Reports, Health
Published
2009

5. High interleukin 17 expression is correlated with better cardiac function in human Chagas disease.

Author

Magalhaes LM, Villani FN, Nunes Mdo C, Gollob KJ, Rocha MO, Dutra WO, Magalhães, Luisa M D, Villani, Fernanda N A, Nunes, Maria do Carmo P, Gollob, Kenneth J, Rocha, Manoel O C, and Dutra, Walderez O

Abstract

This study was designed to investigate whether the expression of interleukin 17 (IL-17) is associated with the indeterminate or cardiac clinical forms of Chagas disease and whether IL-17 expression can be correlated with patients' cardiac function. Our results demonstrated that cardiac Chagas patients have a lower intensity of expression of IL-17 by total lymphocytes and lower frequency of circulating T helper 17 cells. Correlative analysis showed that high IL-17 expression was associated with better cardiac function, as determined by left ventricular ejection fraction and left ventricular diastolic diameter values. Therefore, IL-17 expression can be a protective factor to prevent myocardial damage in human Chagas disease. [ABSTRACT FROM AUTHOR]

Published
2013
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