1. Candida albicans Is Not Always the Preferential Yeast Colonizing Humans: A Study in Wayampi Amerindians.
- Author
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Angebault, Cécile, Djossou, Félix, Abélanet, Sophie, Permal, Emmanuelle, Ben Soltana, Mouna, Diancourt, Laure, Bouchier, Christiane, Woerther, Paul-Louis, Catzeflis, François, Andremont, Antoine, d'Enfert, Christophe, and Bougnoux, Marie-Elisabeth
- Subjects
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CANDIDA albicans , *YEAST , *INTESTINES , *SACCHAROMYCES cerevisiae , *GENOMICS , *INDIGENOUS peoples of the Americas - Abstract
In industrialized countries Candida albicans is considered the predominant commensal yeast of the human intestine, with approximately 40% prevalence in healthy adults. We discovered a highly original colonization pattern that challenges this current perception by studying in a 4- year interval a cohort of 151 Amerindians living in a remote community (French Guiana), and animals from their environment. The prevalence of C. albicans was persistently low (3% and 7% of yeast carriers). By contrast, Candida krusei and Saccharomyces cerevisiae were detected in over 30% of carriers. We showed that C. krusei and S. cerevisiae carriage was of food or environmental origin, whereas C. albicans carriage was associated with specific risk factors (being female and living in a crowded household). We also showed using whole-genome sequence comparison that C. albicans strains can persist in the intestinal tract of a healthy individual over a 4-year period. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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