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Your search keyword '"Huili Zhao"' showing total 2 results
Start Over Author "Huili Zhao" Journal journal of immunology (baltimore, md. : 1950)
2 results on '"Huili Zhao"'

1. IL-21/IL-21R Signaling Aggravated Respiratory Inflammation Induced by Intracellular Bacteria through Regulation of CD4

Author

Wenhao, Niu, Yueyue, Xu, Xiaoyu, Zha, Jiajia, Zeng, Sai, Qiao, Shuaini, Yang, Hong, Zhang, Lu, Tan, Lida, Sun, Gaoju, Pang, Tengli, Liu, Huili, Zhao, Ningbo, Zheng, Yongci, Zhang, and Hong, Bai

Subjects
Inflammation, STAT3 Transcription Factor, Chlamydia muridarum, Interleukins, Intracellular Space, Chlamydia Infections, Th1 Cells, Mice, T-Lymphocyte Subsets, Animals, Th17 Cells, Female, Receptors, Interleukin-21, T-Box Domain Proteins, Lung, Signal Transduction
Abstract

The IL-21/IL-21R interaction plays an important role in a variety of immune diseases; however, the roles and mechanisms in intracellular bacterial infection are not fully understood. In this study, we explored the effect of IL-21/IL-21R on chlamydial respiratory tract infection using a chlamydial respiratory infection model. The results showed that the mRNA expression of IL-21 and IL-21R was increased in

Published
2020

2. IL-27/IL-27R Mediates Protective Immunity against Chlamydial Infection by Suppressing Excessive Th17 Responses and Reducing Neutrophil Inflammation

Author

Lu Tan, Huili Zhao, Sai Qiao, Wenhao Niu, Tengli Liu, Ningbo Zheng, Yingying Tang, Xiaoyu Zha, Shuaini Yang, Gaoju Pang, Hong Zhang, Jiajia Zeng, Yueyue Xu, Lida Sun, Hong Bai, and Yongci Zhang

Subjects
Chemokine, Protective immunity, Chlamydia muridarum, Neutrophils, medicine.medical_treatment, Immunology, Inflammation, Disease, Mice, Immunology and Allergy, Medicine, Animals, Mice, Knockout, biology, business.industry, Interleukins, Respiratory infection, Receptors, Interleukin, biology.organism_classification, Mice, Inbred C57BL, Cytokine, Knockout mouse, biology.protein, Th17 Cells, medicine.symptom, business
Abstract

IL-27, a heterodimeric cytokine of the IL-12 family, has diverse influences on the development of multiple inflammatory diseases. In this study, we identified the protective role of IL-27/IL-27R in host defense against Chlamydia muridarum respiratory infection and further investigated the immunological mechanism. Our results showed that IL-27 was involved in C. muridarum infection and that IL-27R knockout mice (WSX-1–/– mice) suffered more severe disease, with greater body weight loss, higher chlamydial loads, and more severe inflammatory reactions in the lungs than C57BL/6 wild-type mice. There were excessive IL-17–producing CD4+ T cells and many more neutrophils, neutrophil-related proteins, cytokines, and chemokines in the lungs of WSX-1–/– mice than in wild-type mice following C. muridarum infection. In addition, IL-17/IL-17A–blocking Ab treatment improved disease after C. muridarum infection in WSX-1–/– mice. Overall, we conclude that IL-27/IL-27R mediates protective immunity during chlamydial respiratory infection in mice by suppressing excessive Th17 responses and reducing neutrophil inflammation.

Published
2020

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