1. The Immune Injury Effects and Clinical Significance of Eosinophils in Auto-Immune-Related Hematocytopenia.
- Author
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Sun, Li-Fei, Han, Bing, Wu, Qiang-Qiang, Wang, Gui-Chen, Hao, Hong-Feng, Du, Yan-Hui, and Zhang, Yan
- Subjects
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AUTOIMMUNE diseases , *BLOOD diseases , *EOSINOPHILS , *PEROXIDASE , *HLA histocompatibility antigens , *GENE expression , *BLOOD serum analysis - Abstract
Eosinophils (EOS) quantity, active state, peroxidase activity (POX), and HLA-DR expression in bone marrow of 176 Auto-Immune-Related Hematocytopenia (AIRH) patients were analyzed. Immunofluorescent staining (IF) is performed to observe the expression of immunizing molecules on EOS. In serum of AIRH patients the levels of IL-4, IL-5, IL-6, IL-12, IL-17, and IFN-γwere increased but there was no significance on IL-2 level. In marrow of AIRH, activated EOS expressed POX, and other molecules, it played various cell-mediated immunity injury roles to hemocyte. EOS might be possessed with multiple immunological fuctions, it playes an important immune effect in AIRH autoimmune pathological processes. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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