1. Endothelial function of healthy adults from 20 to 91 years of age: prediction of cardiovascular risk by vasoactive range
- Author
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Timo Hinrichs, Jonathan R. Wagner, Christopher Klenk, Arno Schmidt-Trucksäss, Justin Carrard, Mirijam Frei, Raphael Knaier, Achim Schwarz, and Karsten Königstein
- Subjects
Adult ,Male ,medicine.medical_specialty ,Percentile ,Brachial Artery ,Physiology ,Age prediction ,Disease ,030204 cardiovascular system & hematology ,Constriction ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Vasoactive ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,Normal heart ,Receiver operating characteristic ,business.industry ,Vasodilation ,Cardiovascular Diseases ,Heart Disease Risk Factors ,Regional Blood Flow ,Vasoconstriction ,Reference values ,Cardiology ,Female ,Endothelium, Vascular ,Cardiology and Cardiovascular Medicine ,business - Abstract
OBJECTIVES Brachial arterial low flow-mediated constriction (L-FMC) and flow-mediated dilation (FMD) are ultrasound-based biomarkers that emerge into scientific and clinical practice indicating cardiovascular effects of medical and lifestyle-based treatment beyond classical risk factors. This study is the first to provide reference values and to assess the predictive value of L-FMC, FMD and their composite endpoint vasoactive range (VAR) in healthy adults. METHODS L-FMC, FMD and VAR were measured in 457 nonsmoking adults of 20-91 years without chronic diseases, medication, with normal heart function and very low cardiovascular risk. Sex-specific percentiles were calculated and predictive ability for elevated cardiovascular risk was assessed using receiver-operating characteristic (ROC) curves. RESULTS From 20 to 91 years of age, L-FMC increased 86.1 and 105.3%, FMD decreased 63.6 and 47.1% and VAR decreased 58.3 and 55.2% in women and men, respectively. Area under the ROC curves was 0.54 (95% CI = 0.49-0.54) for L-FMC, 0.67 (95% CI = 0.62-0.67) for FMD and 0.72 (95% CI = 0.67-0.72) for VAR (P
- Published
- 2021