1. Differential impact of local and regional aortic stiffness on left ventricular remodeling
- Author
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Gilles Soulat, Elie Mousseaux, Pierre Boutouyrie, Thiago Quinaglia, Mourad Bensalah, Stéphane Laurent, Emilie Bollache, Nadjia Kachenoura, Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Laboratoire d'Imagerie Biomédicale (LIB), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Adult ,Male ,Aortic arch ,medicine.medical_specialty ,Adolescent ,Manometry ,Physiology ,[SDV]Life Sciences [q-bio] ,Aorta, Thoracic ,Blood Pressure ,Pulse Wave Analysis ,030204 cardiovascular system & hematology ,030218 nuclear medicine & medical imaging ,Young Adult ,03 medical and health sciences ,Vascular Stiffness ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,medicine.artery ,Ascending aorta ,Internal Medicine ,medicine ,Humans ,Arterial Pressure ,Ventricular remodeling ,Pulse wave velocity ,Aorta ,Aged ,Aged, 80 and over ,Ventricular Remodeling ,business.industry ,Age Factors ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Healthy Volunteers ,3. Good health ,Pulse pressure ,Mean blood pressure ,Descending aorta ,cardiovascular system ,Cardiology ,Regression Analysis ,Female ,Aortic stiffness ,Cardiology and Cardiovascular Medicine ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; Background: Left ventricular (LV) remodeling and aortic stiffness have independent predictive value for all causes and cardiovascular mortality. Because elastic properties of the arterial wall vary along the aortic pathway, we hypothesized that local and regional aortic stiffness could differently impact on LV remodeling.Methods and results: Regional aortic stiffness was determined from carotid-femoral pulse wave velocity (cfPWV) measured by aplanation tonometry. Aortic arch pulse wave velocity was measured by phase contrast cardiovascular magnetic resonance (CMR). Local stiffness was calculated in the ascending aorta pulse wave velocity (aaPWV) and descending aorta pulse wave velocity using central pulse pressure measurement, cine CMR acquisition, and surface change estimation. CMR LV remodeling was expressed as LV mass to end-diastolic volume ratio.We evaluated 146 study participants (41 ± 15 years) free of overt cardiovascular disease. In stepwise multivariate regression analysis, cfPWV and aaPWV were significantly and independently correlated to mass to end-diastolic volume ratio (partial R = 0.07 and R = 0.10, respectively, all P < 0.005) after adjustment for age, sex, BMI, brachial mean blood pressure, and central pulse pressure. Descending aorta pulse wave velocity was correlated with mass to end-diastolic volume ratio to a lower extent (R = 0.04, P = 0.0115) and aortic arch pulse wave velocity was not independently associated with mass to end-diastolic volume ratio. CfPWV and aaPWV were both independently associated with mass to end-diastolic volume ratio, explaining 5 and 8% of mass to end-diastolic volume ratio variance, respectively.Conclusion: In study participants free of overt cardiovascular disease, stiffness of the ascending aorta representing the local proximal aortic function face to the LV and of the downstream aortic pathway assessed by cfPWV reflecting more advanced alterations of material properties involving the entire aorta, are independent determinants of LV remodeling after adjustment to age, BMI, mean blood pressure, and sex.
- Published
- 2018
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