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Your search keyword '"Lacidipine"' showing total 6 results
Start Over Descriptor "Lacidipine" Journal journal of human hypertension
6 results on '"Lacidipine"'

1. Lercanidipine vs lacidipine in isolated systolic hypertension.

Author

Millar-Craig, M., Shaffu, B., Greenough, A., Mitchell, L., and McDonald, C.

Subjects
*LACIDIPINE, *HYPERTENSION, *BLOOD pressure measurement, *BLOOD pressure, *ANTIHYPERTENSIVE agents
Abstract

This randomised, double-blind, double-dummy, parallel group, multicentre study compared the efficacy and tolerability of lercanidipine with lacidipine. Elderly patients with isolated systolic hypertension (supine blood pressure ?160/<95?mmHg) were enrolled and underwent a placebo run-in period of 14-27 days before random allocation to lercanidipine tablets 10?mg once daily (n=111) or lacidipine tablets 2?mg once daily (n=111) for the assessment period (112-160 days). Titration to lercanidipine 20?mg once daily (two 10?mg tablets) or lacidipine 4?mg once daily (two 2?mg tablets) was allowed after 8 weeks, if required. Both treatments decreased supine and standing systolic and diastolic blood pressure between the end of the run-in period and the end of the assessment period (P<0.0001). At the end of the assessment period, the estimated mean treatment difference (95% confidence intervals) in supine systolic blood pressure was -0.81 (-4.45, 2.84)?mmHg. These confidence intervals were within the limits specified for equivalence, that is, (-5, 5) mmHg. Ambulatory blood pressure monitoring showed that the antihypertensive effects of both drugs lasted for the full 24-h dosing period and followed a circadian pattern. Both treatments were well tolerated with a low incidence of adverse drug reactions and a low withdrawal rate. Significantly fewer patients withdrew from treatment with lercanidipine (P=0.015). Neither treatment had any clinically significant effect on pulse rate or cardiac conduction. In conclusion, both treatments were equally effective in controlling supine systolic blood pressure in patients with isolated systolic hypertension.Journal of Human Hypertension (2003) 17, 799-806. doi:10.1038/sj.jhh.1001614 [ABSTRACT FROM AUTHOR]

Published
2003
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2. Effect of lacidipine on blood pressure, vasoactive hormones, and haemorheology in elderly patients with essential hypertension.

Author

Shand, B I, Gilchrist, N L, Nicholls, M G, and Caesar, M

Subjects
*ESSENTIAL hypertension, *LACIDIPINE, *HEMORHEOLOGY
Abstract

Discusses the effect of lacidipine on blood pressure, vasoactive hormones and haemorheology in elderly patients with essential hypertension. Stimulation of renin release through the use of calcium antagonists; Improvement in intrinsic red blood cell rheology through the treatment of hypertension with lacidipine.

Published
2000
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5. Lercanidipine vs lacidipine in isolated systolic hypertension

Author

M Millar-Craig, C McDonald, A Greenough, B Shaffu, and L Mitchell

Subjects
Male, Dihydropyridines, Ambulatory blood pressure, Supine position, Blood Pressure, Double-Blind Method, Cardiac conduction, Internal Medicine, medicine, Supine Position, Humans, Systole, Aged, Aged, 80 and over, business.industry, Lercanidipine, Blood Pressure Monitoring, Ambulatory, Middle Aged, Calcium Channel Blockers, Blood pressure, Treatment Outcome, Tolerability, Lacidipine, Anesthesia, Hypertension, Female, business, medicine.drug
Abstract

This randomised, double-blind, double-dummy, parallel group, multicentre study compared the efficacy and tolerability of lercanidipine with lacidipine. Elderly patients with isolated systolic hypertension (supine blood pressure ⩾160/

Published
2003

6. Effect of lacidipine and nifedipine GITS on platelet function in patients with essential hypertension

Author

Manuel Velasco, M.C. Armas-Padilla, Beatriz Pacheco, A.R. Carvajal, A Castillo-Moreno, M.J. Armas-Hernández, and Rafael Hernández-Hernández

Subjects
Blood Platelets, Male, Dihydropyridines, Nifedipine, Platelet Aggregation, Posture, Blood Pressure, Pharmacology, Essential hypertension, Heart Rate, Malondialdehyde, Internal Medicine, Medicine, Humans, In patient, Platelet, Single-Blind Method, Arachidonic Acid, business.industry, Middle Aged, medicine.disease, Nifedipine gits, Lacidipine, Hypertension, Female, Calcium Channels, business, Biomarkers, medicine.drug
Abstract

With the aim of evaluating the effects on blood pressure, platelet function and insulin sensitivity of the dihydropiridines lacidipine and nifedipine GITS, a parallel double-blind study was carried out in a group of 20 patients with mild to moderate essential hypertension. They received a placebo for 4 weeks; then were divided at random into two groups of 10 patients each. Nifedipine GITS, 30 mg and lacidipine, 4 mg, were given during 16 weeks of active treatment. Blood pressure and heart rate were measured at the clinic in supine, sitting and standing positions, 24 +/- 1 h after the last dose. After the placebo and active phases were carried out, a platelet aggregation test was performed to determine platelet malondialdehyde production and a tolerance to 100 g of glucose by measuring glucaemia and plasma insulin. Both drugs reduced systolic and diastolic blood pressure at the same level, however there were observable differences in the rate of reduction. The nifedipine GITS reduced supine systolic blood pressure by 25 mm Hg in the first week, while the lacidipine did so by 11 mm Hg. At the end of the study period nifedipine reduced supine systolic blood pressure by 28 mm Hg and lacidipine by 20 mm Hg. Heart rate was increased slightly but significantly in the nifedipine GITS group only in the standing position. Both drugs reduced platelet aggregation ex vivo only marginally but they modified the malondialdehyde production, indicating an action on the arachidonic acid metabolic pathway.

Published
2000

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