Search

Your search keyword '"Shiba, T."' showing total 7 results
Start Over Author "Shiba, T." Journal journal of human genetics
7 results on '"Shiba, T."'

4. Isolation and radiation hybrid mapping of a dinucleotide repeat polymorphism at the human calcium-sensing receptor (CASR) locus.

Author

Tsukamoto K, Watanabe I, Shiba T, and Emi M

Subjects
Alleles, Base Sequence, Gene Frequency, Humans, Molecular Sequence Data, Parathyroid Glands chemistry, Polymerase Chain Reaction, Polymorphism, Genetic, Receptors, Calcium-Sensing, Calcium physiology, Chromosomes, Human, Pair 3, Dinucleotide Repeats genetics, Receptors, Cell Surface genetics
Abstract

Calcium-sensing receptor (CASR) in parathyroid gland regulates calcium homeostasis by sensing decreases in extracellular calcium levels and effecting an increase in secretion of parathyroid hormone. A polymorphic dinucleotide (CA) sequence was isolated from a genomic clone containing the human CASR gene and was mapped to 3q13.3-q21. This polymorphism will be useful in the genetic study of disorders affecting calcium metabolism, such as hypercalcemia, hypocalcemia, osteoporosis, hyperparathyroidism, and hypoparathyroidism.

Published
1998
Full Text
View/download PDF

5. Isolation and mapping of a polymorphic CA repeat sequence at the human interleukin 6 locus.

Author

Tsukamoto K, Haruta K, Shiba T, and Emi M

Subjects
Alleles, Base Sequence, Calcium metabolism, Chromosome Mapping, DNA Primers genetics, Gene Frequency, Hematologic Diseases genetics, Humans, Hybrid Cells, Inflammation genetics, Polymerase Chain Reaction, Polymorphism, Genetic, Dinucleotide Repeats, Interleukin-6 genetics
Abstract

A polymorphic dinucleotide (CA) sequence was isolated from a genomic clone containing the human interleukin 6 (interferon beta-2) gene and was mapped to 7p21. This polymorphism will be useful in the genetic study of disorders affecting the inflammation process, calcium metabolism, and hematologic malignancies.

Published
1998
Full Text
View/download PDF

6. Isolation of a polymorphic CA repeat sequence at the human progesterone receptor (PGR) locus.

Author

Tsukamoto K, Watanabe I, Shiba T, and Emi M

Subjects
Alleles, Female, Gene Frequency, Genetic Markers, Humans, Polymerase Chain Reaction, Polymorphism, Genetic, Chromosomes, Human, Pair 11, Dinucleotide Repeats, Receptors, Progesterone genetics
Abstract

We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the human progesterone receptor (PGR) gene. This polymorphism will be a useful marker in the genetic study of disorders affecting female endocrine systems, such as progesterone resistance and breast, uterine, and ovarian cancers.

Published
1998
Full Text
View/download PDF

7. Isolation and radiation hybrid mapping of dinucleotide repeat polymorphism at the human matrix Gla protein (MGP) locus.

Author

Watanabe I, Tsukamoto K, Shiba T, and Emi M

Subjects
Alleles, Base Sequence, Chromosome Mapping, DNA Primers genetics, Gene Frequency, Humans, Hybrid Cells, Polymerase Chain Reaction, Polymorphism, Genetic, Matrix Gla Protein, Calcium-Binding Proteins genetics, Dinucleotide Repeats, Extracellular Matrix Proteins
Abstract

Matrix Gla protein (MGP) is an 84-residue, vitamin K-dependent protein expressed by chondrocytes and vascular smooth muscle cells, and is a potent regulator of calcium deposition in cartilage and arterial wall. We isolated a polymorphic dinucleotide CA repeat marker from a genomic clone containing the human MGP gene. This polymorphism will be useful in genetic studies of arteriosclerosis and osteoporosis.

Published
1998
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results