1. Risk factors for acquisition of OXA-48-producing Klebsiella pneumonia among contact patients: a multicentre study
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Caroline Neulier, Alexandra Lomont, J. Merrer, B. Grandbastien, J.C. Lucet, Jean-Ralph Zahar, Delphine Hilliquin, V. Thepot Seegers, Didier Lepelletier, R. Le Guern, Anne-Marie Rogues, C. Legeay, V. Marie, CHU Lille, Université de Lille, Centre Hospitalier Universitaire d'Angers [CHU Angers], Recherche translationnelle : relations hôte-pathogènes - EA 7366, Recherche translationelle relations hôte-pathogènes, Institut de Cancérologie de l'Ouest [Angers/Nantes] [UNICANCER/ICO], AP-HP - Hôpital Bichat - Claude Bernard [Paris], CHU de Bordeaux Pellegrin [Bordeaux], Centre hospitalier universitaire de Nantes [CHU Nantes], Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille], CHU Necker - Enfants Malades [AP-HP], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Nantes (CHU Nantes), and Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
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0301 basic medicine ,Multivariate analysis ,[SDV]Life Sciences [q-bio] ,Mesh:Adult ,0302 clinical medicine ,Mesh:Risk Factors ,Mesh:Case-Control Studies ,030212 general & internal medicine ,Mesh:Aged ,Mesh:Klebsiella pneumoniae/enzymology ,OXA-48 ,Aged, 80 and over ,Mesh:Klebsiella Infections/microbiology ,Univariate analysis ,Screening ,Contact patients ,Carbapenemases ,Carbapenemase-producing ,Risk factors ,Enterobacteriaceae ,General Medicine ,Middle Aged ,3. Good health ,Klebsiella pneumoniae ,Infectious Diseases ,Mesh:Klebsiella Infections/epidemiology ,Adult ,Microbiology (medical) ,medicine.medical_specialty ,030106 microbiology ,Mesh:Young Adult ,beta-Lactamases ,Young Adult ,03 medical and health sciences ,Mesh:Retrospective Studies ,Mesh:Klebsiella pneumoniae/isolation & purification ,Mesh:Middle Aged ,Internal medicine ,Mesh:80 and over ,medicine ,Humans ,Aged ,Retrospective Studies ,business.industry ,Case-control study ,Retrospective cohort study ,Odds ratio ,medicine.disease ,Confidence interval ,Klebsiella Infections ,Mesh:beta-Lactamases/analysis ,Surgery ,Mesh:Humans ,Case-Control Studies ,Concomitant ,Klebsiella pneumonia ,business - Abstract
International audience; BACKGROUND: Cohorting carbapenemase-producing Enterobacteriaceae (CPE) carriers during hospitalization limits in-hospital spreading.OBJECTIVE: To identify risk factors for CPE acquisition among contacts of an index patient in non-cohorted populations.METHODS: A multicentre retrospective matched case-control study was conducted in five hospitals. Each contact patient (case) who acquired Klebsiella pneumoniae (KP)-OXA-48 from an index patient was compared to three contact (controls) with the same index patients matched with hospitalization in the same unit and similar exposure times.RESULTS: Fifty-one secondary cases and 131 controls were included. By univariate analysis, exposure time (odds ratio: 1.06; 95% confidence interval: 1.02-1.1; P = 0.006), concomitant infection at admission (3.23; 1.42-7.35; P = 0.005), antimicrobial therapy within the last month before hospitalization (2.88; 1.34-6.2; P = 0.007), antimicrobial therapy during the exposure time (5.36; 2.28-12.6; P
- Published
- 2018
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