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Early in the epidemic, HIV infection and AIDS were rarely diagnosed in women. Today, the HIV/AIDS epidemic represents a growing and persistent health threat to women, especially young women. The purpose of the current study was to conduct an international study with female undergraduate college students to assess knowledge and attitudes about HIV/AIDS, current and future sexual behaviors, and condom use self-efficacy. Participants included several convenience samples of female undergraduate college students from three public universities in the southern region of the United States (n = 112), a large public university in Australia (n = 66), and a public university in Hong Kong (n = 93). This research study utilizes a quantitative survey research design. Seventy-seven percent of American women and 66% of Australian women were sexually active compared with only 21% of Chinese women (χ2 = 67.74, p < .001). Of the sexually active women, 86% of Australian women reported regular use of safer sex practices during the past year compared with 69% of American women and 20% of Chinese women (χ2 = 8.9, p < .05). Although the sample as a whole scored generally high on HIV/AIDS awareness, it is not reflected in safe sex practices or intentions for future safe sex practices. Future studies should focus on further understanding the social, cultural, and psychological factors that hamper safe sex practices among this population as well as successful intervention strategies to overcome these barriers. [ABSTRACT FROM AUTHOR]