1. The synthesis of four isomeric bisthienothiepinones
- Author
-
Joseph M. Muchowski, Jeffrey A. Charonnat, and Peter H. Nelson
- Subjects
chemistry.chemical_classification ,Chemistry ,Sodium ,Carboxylic acid ,Organic Chemistry ,chemistry.chemical_element ,Basic hydrolysis ,Chloride ,chemistry.chemical_compound ,Thioether ,medicine ,Organic chemistry ,Single displacement reaction ,medicine.drug - Abstract
The displacement reaction between sodium thiophene-3-thiolate and methyl 3-(bromomethyl)thiophene-2-carboxylate (5) gave the expected thioether 7a. Basic hydrolysis afforded the carboxylic acid 7b; conversion to the acid chloride, and treatment of the latter with stannic chloride then produced the bisthienothiepinone 1. Using analogous reactions the isomers 2-4 were also synthesized.
- Published
- 1983
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