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Start Over Author "Ruben Hernandez" Journal journal of hepatology
10 results on '"Ruben Hernandez"'

1. Visualization of the therapeutic efficacy of a gene correction approach in Wilson's disease by laser-ablation inductively coupled mass spectrometry

Author

Ralf Weiskirchen, Ruben Hernandez-Alcoceba, Daniel Moreno, Cristina Gazquez, Oihana Murillo, Ricarda Uerlings, and Gloria González-Aseguinolaza

Subjects
0301 basic medicine, Male, Genetic enhancement, Mass spectrometry, 01 natural sciences, Mass Spectrometry, 03 medical and health sciences, Dependovirus, Mice, Hepatolenticular Degeneration, medicine, Animals, Humans, Gene, Mice, Knockout, Laser ablation, Hepatology, Chemistry, Targeted Gene Repair, 010401 analytical chemistry, medicine.disease, 0104 chemical sciences, Wilson's disease, 030104 developmental biology, Liver, Copper-Transporting ATPases, Copper-transporting ATPases, Cancer research, Copper
Published
2017

2. Molecular characterization of autophagic and apoptotic signaling induced by Sorafenib in liver cancer cells: In vitro and in vivo studies

Author

Luis Contreras, J. De la Cruz, Elena Navarro-Villarán, Ruben Hernandez Ordoñez, José L. Mauriz, Mario Rodríguez-Arribas, L.M.M. Gómez, José M. Fuentes, Jordi Muntané, José L. Quiles, Roberto Gonzalez, J.A.D.C. Castillo, María A. Rodríguez-Hernández, Á.J. De la Rosa, J.M. Álamo-Martínez, Francisco J. Padillo, Paloma Gallego, and Javier González-Gallego

Subjects
Sorafenib, Hepatology, Chemistry, In vivo, Apoptosis, Autophagy, Cancer research, medicine, Liver cancer, medicine.disease, In vitro, medicine.drug
Published
2018

3. FRI-430-Preclinical validation of copper 64 as a translational tool for evaluating the pharmacodynamics of VTX-801 genen therapy in Wilson’s disease

Author

Iván Peñuelas, María Collantes, Daniel Moreno, Oihana Murillo-Sauca, Jean Philippe Combal, Ruben Hernandez, Veronica Ferrer, Cristina Gazquez, Margarita Ecay, Gloria González-Aseguinolaza, Bernard Bénichou, and Anne Douar

Subjects
Wilson's disease, Oncology, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Pharmacodynamics, Medicine, business, medicine.disease
Published
2019

4. Improvement of gene therapy for Wilson’s disease

Author

O. Murillo-Sauca, Cristina Gazquez, Gloria González-Aseguinolaza, Ruben Hernandez-Alcoceba, D. Moreno-Luqui, and Iñigo Navarro-Blasco

Subjects
Oncology, Wilson's disease, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Genetic enhancement, medicine, business, medicine.disease
Published
2017

5. Long-term metabolic correction of Wilson's disease in a murine model by gene therapy

Author

Jesús Prieto, Ruben Hernandez-Alcoceba, Iñigo Navarro-Blasco, Daniel Moreno Luqui, Jose Ignacio Monreal, Armando Moreno-Cermeño, Debora Martinez-Espartosa, Cristina Gazquez, Gloria González-Aseguinolaza, Oihana Murillo, Fernando J. Corrales, and Laura Guembe

Subjects
0301 basic medicine, medicine.medical_specialty, Urinary system, Genetic enhancement, Genetic Vectors, chemistry.chemical_element, Disease, Biology, Excretion, 03 medical and health sciences, Mice, 0302 clinical medicine, Hepatolenticular Degeneration, Internal medicine, medicine, Animals, Humans, Cation Transport Proteins, Adenosine Triphosphatases, Hepatology, Therapeutic effect, Gene Transfer Techniques, Histology, Genetic Therapy, medicine.disease, Copper, Peptide Fragments, Wilson's disease, Disease Models, Animal, 030104 developmental biology, Endocrinology, Treatment Outcome, chemistry, Liver, Copper-Transporting ATPases, alpha 1-Antitrypsin, Disease Progression, 030211 gastroenterology & hepatology
Abstract

Background & Aims Wilson's disease (WD) is an autosomal recessively inherited copper storage disorder due to mutations in the ATP7B gene that causes hepatic and neurologic symptoms. Current treatments are based on lifelong copper chelating drugs and zinc salts, which may cause side effects and do not restore normal copper metabolism. In this work we assessed the efficacy of gene therapy to treat this condition. Methods We transduced the liver of the Atp7b −/− WD mouse model with an adeno-associated vector serotype 8 (AAV8) encoding the human ATP7B cDNA placed under the control of the liver-specific α1-antitrypsin promoter (AAV8-AAT-ATP7B). After vector administration we carried out periodic evaluation of parameters associated with copper metabolism and disease progression. The animals were sacrificed 6months after treatment to analyze copper storage and hepatic histology. Results We observed a dose-dependent therapeutic effect of AAV8-AAT-ATP7B manifested by the reduction of serum transaminases and urinary copper excretion, normalization of serum holoceruloplasmin, and restoration of physiological biliary copper excretion in response to copper overload. The liver of treated animals showed normalization of copper content and absence of histological alterations. Conclusions Our data demonstrate that AAV8-AAT-ATP7B-mediated gene therapy provides long-term correction of copper metabolism in a clinically relevant animal model of WD providing support for future translational studies.

Published
2015

6. 1134 AAV MEDIATED LIVER GENE THERAPY PROVIDES PROLONGED ENZYMATIC CORRECTION AND PROTECTS AGAINST INDUCED MOTOR NEUROPATHY IN ACUTE INTERMITTENT PORPHYRIA MICE

Author

Itsaso Mauleón, Manuel Alegre, A. Fontanellas, Javier Prieto, R. Enríquez de Salamanca, Harald Petry, Carmen Unzu, Stuart G. Beattie, Maria Sol Rodriguez-Pena, Gloria González-Aseguinolaza, Ana Sampedro, Ignacio Melero, Ruben Hernandez-Alcoceba, Julio Artieda, E.J. Timmermans, and Jaap Twisk

Subjects
chemistry.chemical_classification, medicine.medical_specialty, Hepatology, business.industry, Genetic enhancement, medicine.disease, Enzyme, Endocrinology, chemistry, Internal medicine, medicine, business, Motor neuropathy, Acute intermittent porphyria
Published
2010

7. [383] INTRAHEPATIC INJECTION OF ADENOVIRUS REDUCES INFLAMMATION AND INCREASES GENE TRANSFER AND THERAPEUTIC EFFECT IN MICE

Author

Itsaso Mauleón, Gloria González-Aseguinolaza, Ruben Hernandez-Alcoceba, Stefan Kochanek, Laura Ochoa, Julien Crettaz, Javier Prieto, N. van Rooijen, Pedro Berraondo, Cheng Qian, Miguel Barajas, and Veijay Shankar

Subjects
Hepatology, business.industry, Therapeutic effect, Cancer research, Medicine, Gene transfer, Inflammation, medicine.symptom, business, Molecular biology
Published
2007

8. 273 PROPERTIES AND LIMITATIONS OF MONOCYTES AND CANCER CELLS AS CARRIERS FOR REPLICATION-COMPETENT ADENOVIRAL VECTORS IN LIVER METASTASES OF PANCREATIC CANCER

Author

Sergia Bortolanza, Ruben Hernandez-Alcoceba, Eva Garcia-Aragoncillo, Javier Prieto, Raquel Casado, and Maria Bunuales

Subjects
Oncology, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Pancreatic cancer, Replication (statistics), Cancer cell, Medicine, CA19-9, business, medicine.disease
Published
2012

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