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Start Over Author "Pateron D" Journal journal of hepatology
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12. Serum type I collagen and N-terminal peptide of type III procollagen in chronic hepatitis. Relationship to liver histology and conventional liver tests.

Author

Trinchet JC, Hartmann DJ, Pateron D, Laarif M, Callard P, Ville G, and Beaugrand M

Subjects
Adult, Aged, Aged, 80 and over, Alanine Transaminase blood, Chronic Disease, Female, Hepatitis complications, Hepatitis pathology, Hepatitis, Chronic complications, Hepatitis, Chronic pathology, Humans, Liver Cirrhosis etiology, Liver Cirrhosis pathology, Liver Function Tests, Male, Middle Aged, gamma-Globulins metabolism, Collagen blood, Hepatitis blood, Hepatitis, Chronic blood, Liver pathology, Peptide Fragments blood, Procollagen blood
Abstract

The aim of this study was to compare serum N-terminal peptide of type III procollagen to aminotransferases and gamma-globulins as a marker for histological activity in patients with chronic hepatitis and to assess the role of type I collagen, a new serum marker, as a marker of fibrosis in these patients. Sixty patients with biopsy-proven chronic hepatitis were included in this study. Liver disease was virus B-related in 29, autoimmune in five, drug-induced in five, and of unknown etiology in 21. Each biopsy was independently assessed by two liver pathologists. Two histological scores, a score of activity and a score of fibrosis, were established. Serum N-terminal peptide of type III procollagen and type I collagen were assayed by liquid phase RIA. Significant correlations were noted between serum N-terminal peptide of type III procollagen and scores of activity (r = 0.70, p less than 10(-4)) and fibrosis (r = 0.45, p = 0.0005), and between serum type I collagen and scores of activity (r = 0.46, p = 0.0004) and fibrosis (r = 0.67, p less than 10(-4)). When the correlation between scores of activity and fibrosis (r = 0.52, p = 10(-4)) was considered by partial correlation, serum N-terminal peptide of type III procollagen was correlated with the score of activity (r = 0.63, p less than 10(-3)) but not with the score of fibrosis, and serum type I collagen was correlated with the score of fibrosis (r = 0.58, p less than 10(-3)), but not with the score of activity.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1991
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