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Your search keyword '"Marck, E."' showing total 19 results
Start Over Author "Marck, E." Journal journal of hepatology
19 results on '"Marck, E."'

1. 1334 CORRELATION OF HUMAN LIVER PPAR GENE EXPRESSION WITH HISTOLOGICAL SEVERITY OF NASH AND ASSOCIATED METABOLIC DERANGEMENTS: RATIONALE FOR TARGETED THERAPY

Author

Francque, S.M., primary, Verrijken, A., additional, Caron, S., additional, Prawitt, J., additional, Taskinen, M.-R., additional, Van Hul, W., additional, Mertens, I., additional, Hubens, G., additional, Van Marck, E., additional, Staels, B., additional, Michielsen, P., additional, and Van Gaal, L., additional

Published
2013
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5. 1235 SEVERE STEATOSIS IS ASSOCIATED WITH A HAEMODYNAMICALLY SIGNIFICANT INCREASE IN INTRAHEPATIC RESISTANCE IN ASSOCIATION WITH BOTH ENDOTHELIAL DYSFUNCTION AND MORPHOLOGICAL ALTERATIONS IN A RAT MODEL

Author

Francque, S., primary, Laleman, W., additional, Verbeke, L., additional, Van Steenkiste, C., additional, Casteleyn, C., additional, Kwanten, W., additional, Van Dijck, C., additional, D'Hondt, M., additional, Ramon, A., additional, Vermeulen, W., additional, De Winter, B., additional, Van Marck, E., additional, Pelckmans, P., additional, and Michielsen, P., additional

Published
2012
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17. PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis.

Author

Francque S, Verrijken A, Caron S, Prawitt J, Paumelle R, Derudas B, Lefebvre P, Taskinen MR, Van Hul W, Mertens I, Hubens G, Van Marck E, Michielsen P, Van Gaal L, and Staels B

Subjects
Adolescent, Adult, Aged, Biopsy, Female, Follow-Up Studies, Humans, Liver metabolism, Male, Middle Aged, Non-alcoholic Fatty Liver Disease metabolism, Non-alcoholic Fatty Liver Disease therapy, PPAR alpha biosynthesis, Prospective Studies, Real-Time Polymerase Chain Reaction, Young Adult, Gene Expression Regulation, Liver pathology, Non-alcoholic Fatty Liver Disease genetics, PPAR alpha genetics, RNA genetics
Abstract

Background & Aims: Peroxisome proliferator-activated receptors (PPARs) have been implicated in non-alcoholic steatohepatitis (NASH) pathogenesis, mainly based on animal data. Gene expression data in NASH patients are scarce. We studied liver PPARα, β/δ, and γ expression in a large cohort of obese patients assessed for presence of NAFLD at baseline and 1 year follow-up., Methods: Patients presented to the obesity clinic underwent a hepatic work-up. If NAFLD was suspected, liver biopsy was performed. Gene expression was studied by mRNA quantification. Patients were reassessed after 1 year., Results: 125 patients were consecutively included in the study, of which 85 patients had paired liver biopsy taken at 1 year of follow-up. Liver PPARα expression negatively correlated with the presence of NASH (p=0.001) and with severity of steatosis (p=0.003), ballooning (p=0.001), NASH activity score (p=0.008) and fibrosis (p=0.003). PPARα expression was positively correlated to adiponectin (R(2)=0.345, p=0.010) and inversely correlated to visceral fat (R(2)=-0.343, p<0.001), HOMA IR (R(2)=-0.411, p<0.001) and CK18 (R(2)=-0.233, p=0.012). Liver PPARβ/δ and PPARγ expression did not correlate with any histological feature nor with glucose metabolism or serum lipids. At 1 year, correlation of PPARα expression with liver histology was confirmed. In longitudinal analysis, an increase in expression of PPARα and its target genes was significantly associated with histological improvement (p=0.008)., Conclusion: Human liver PPARα gene expression negatively correlates with NASH severity, visceral adiposity and insulin resistance and positively with adiponectin. Histological improvement is associated with an increase in expression of PPARα and its target genes. These data might suggest that PPARα is a potential therapeutic target in NASH., (Copyright © 2015. Published by Elsevier B.V.)

Published
2015
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19. Amoxycillin/clavulanic acid induced cholestasis.

Author

Michielsen PP, Van Outryve MJ, Van Marck EA, De Maeyer MH, Pelckmans PA, and Van Maercke YM

Subjects
Adult, Alkaline Phosphatase blood, Amoxicillin therapeutic use, Angina Pectoris drug therapy, Bilirubin blood, Cholestasis, Intrahepatic blood, Cholestasis, Intrahepatic pathology, Clavulanic Acids therapeutic use, Humans, Liver pathology, Male, Amoxicillin adverse effects, Cholestasis, Intrahepatic chemically induced, Clavulanic Acids adverse effects
Published
1990
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