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Your search keyword '"Kaji, Kosuke"' showing total 10 results
Start Over Author "Kaji, Kosuke" Journal journal of hepatology
10 results on '"Kaji, Kosuke"'

2. THU-499-Angiotensin receptor blockade attenuates cholangiocarcinoma cell growth by inhibiting the oncogenic activity of Yes-associated protein

Author

Tsuji, Yuki, primary, Kaji, Kosuke, additional, Saikawa, Soichiro, additional, Seki, Kenichiro, additional, Sato, Shinya, additional, Nakanishi, Keisuke, additional, Kawaratani, Hideto, additional, Kitade, Mitsuteru, additional, Moriya, Kei, additional, Namisaki, Tadashi, additional, and YOSHIJI, Hitoshi, additional

Published
2019
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4. THU-291-Is non-alcoholic fatty liver disease a risk factor for chronic kidney disease?

Author

Akahane, Takemi, primary, Namisaki, Tadashi, additional, Moriya, Kei, additional, Kawaratani, Hideto, additional, Kaji, Kosuke, additional, Takaya, Hiroaki, additional, Shimozato, Naotaka, additional, Sato, Shinya, additional, Sawada, Yasuhiko, additional, Nakanishi, Keisuke, additional, Furukawa, Masanori, additional, Fujinaga, Yukihisa, additional, Tsuji, Yuki, additional, and YOSHIJI, Hitoshi, additional

Published
2019
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5. FRI-332-Effect of combined farnesoid X receptor agonist and angiotensin 2 receptor blocker on established liver fibrosis in rats

Author

Namisaki, Tadashi, primary, Kaji, Kosuke, additional, Nakanishi, Keisuke, additional, Tsuji, Yuki, additional, Sato, Shinya, additional, Sawada, Yasuhiko, additional, Akahane, Takemi, additional, Furukawa, Masanori, additional, Fujinaga, Yukihisa, additional, Takaya, Hiroaki, additional, and YOSHIJI, Hitoshi, additional

Published
2019
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6. FRI-342-Combining probiotics and an angiotensin-2 type 1 receptor blocker has beneficial effects on hepatic fibrogenesis in a rat model of non-alcoholic steatohepatitis

Author

Sawada, Yasuhiko, primary, Kawaratani, Hideto, additional, Kubo, Takuya, additional, Fujinaga, Yukihisa, additional, Furukawa, Masanori, additional, Saikawa, Soichiro, additional, Sato, Shinya, additional, Seki, Kenichiro, additional, Takaya, Hiroaki, additional, Okura, Yasushi, additional, Kaji, Kosuke, additional, Shimozato, Naotaka, additional, Kitade, Mitsuteru, additional, Moriya, Kei, additional, Namisaki, Tadashi, additional, Akahane, Takemi, additional, and Yoshiji, Hitoshi, additional

Published
2019
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8. FRI-020-Identification of risk factors for histological progression with sequential liver biopsies in primary cholangitis patients

Author

Fujinaga, Yukihisa, primary, Namisaki, Tadashi, additional, Akahane, Takemi, additional, Kaji, Kosuke, additional, Takaya, Hiroaki, additional, Sato, Shinya, additional, Moriya, Kei, additional, Kawaratani, Hideto, additional, Sawada, Yasuhiko, additional, Furukawa, Masanori, additional, Tsuji, Yuki, additional, and Yoshiji, Hitoshi, additional

Published
2019
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9. Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma

Author

Yoshiji, Hitoshi, primary, Noguchi, Ryuichi, additional, Toyohara, Masahisa, additional, Ikenaka, Yasuhide, additional, Kitade, Mitsuteru, additional, Kaji, Kosuke, additional, Yamazaki, Masaharu, additional, Yamao, Junichi, additional, Mitoro, Akira, additional, Sawai, Masayoshi, additional, Yoshida, Motoyuki, additional, Fujimoto, Masao, additional, Tsujimoto, Tatsuhiro, additional, Kawaratani, Hideto, additional, Uemura, Masahito, additional, and Fukui, Hiroshi, additional

Published
2009
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10. Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma

Author

Yoshiji, Hitoshi, Noguchi, Ryuichi, Toyohara, Masahisa, Ikenaka, Yasuhide, Kitade, Mitsuteru, Kaji, Kosuke, Yamazaki, Masaharu, Yamao, Junichi, Mitoro, Akira, Sawai, Masayoshi, Yoshida, Motoyuki, Fujimoto, Masao, Tsujimoto, Tatsuhiro, Kawaratani, Hideto, Uemura, Masahito, and Fukui, Hiroshi

Subjects
*VITAMIN K, *ACE inhibitors, *LIVER cancer, *CANCER relapse, *CANCER chemoprevention, *NEOVASCULARIZATION, *VASCULAR endothelial growth factors, *COMBINATION drug therapy
Abstract

Background/Aims: No chemopreventive agent has been approved against hepatocellular carcinoma (HCC) yet. Since neovascularization plays a pivotal role in HCC, an angiostatic agent is considered as one of the promising approaches. The aim of this study was to elucidate the combined effect of the clinically used vitamin K2 (VK) and angiotensin-converting enzyme inhibitor (ACE-I) on cumulative recurrence after curative treatment on a total of 87 patients, especially in consideration of neovascularization. Methods: VK (menatetrenone; 45mg/day) and/or ACE-I (perindopril; 4mg/day) were administered for 36–48 months after curative therapy for HCC. The cumulative recurrence and several indices were analyzed. Results: A 48-month follow-up revealed that the combination treatment with VK and ACE-I markedly inhibited the cumulative recurrence of HCC in association with suppression of the serum level of the vascular endothelial growth factor (VEGF); a central angiogenic factor. The serum level of lectin-reactive α-fetoprotein was also suppressed almost in parallel with VEGF. These beneficial effects were not observed with single treatment using VK or ACE-I. Conclusions: The combination treatment of VK and ACE-I may suppress the cumulative recurrence of HCC after the curative therapy, at least partly through suppression of the VEGF-mediated neovascularization. [Copyright &y& Elsevier]

Published
2009
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