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Start Over Author "Combet C" Journal journal of hepatology
10 results on '"Combet C"'

1. Identification of hepatitis B virus core protein nuclear interacting factors points to RNA binding proteins as major regulators of HBV replication

Author

Chabrolles, H., primary, Vegna, S., additional, Héloïse, A., additional, Couté, Y., additional, Belmudes, L., additional, Kim, Y., additional, Arnold, L., additional, Grierson, D., additional, Chabot, B., additional, Combet, C., additional, Zoulim, F., additional, Lucifora, J., additional, Durantel, D., additional, and Salvetti, A., additional

Published
2018
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3. Interferon-free direct-acting antiviral therapy decreases the rate of hepatocellular carcinoma recurrence in patients with chronic hepatitis C and advanced fibrosis

Author

Virlogeux, V., primary, Pradat, P., additional, Hartig-Lavie, K., additional, Bailly, F., additional, Maynard, M., additional, Ouziel, G., additional, Poinsot, D., additional, Lebosse, F., additional, Ecochard, M., additional, Radenne, S., additional, Benmakhlouf, S., additional, Koffi, J., additional, Lack, P., additional, Scholtes, C., additional, Uhres, A.-C., additional, Ducerf, C., additional, Mabrut, J.-Y., additional, Rode, A., additional, Levrero, M., additional, Combet, C., additional, Merle, P., additional, and Zoulim, F., additional

Published
2017
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8. 784 CELL ENTRY FACTOR USAGE AND VIRAL EVASION IN HEPATITIS C VIRUS INFECTION IN VIVO

Author

Carolla, P., primary, Fofana, I., additional, Fafi-Kremer, S., additional, Zahid, M.N., additional, Cury, K., additional, Turek, M., additional, Bastien-Valle, M., additional, Cosset, F.-L., additional, Pietschmann, T., additional, Hayer, J., additional, Combet, C., additional, Habersetzer, F., additional, Doffoël, M., additional, Keck, Z.-Y., additional, Foung, S.K.H., additional, Zeisel, M.B., additional, Stoll-Keller, F., additional, and Baumert, T.F., additional

Published
2011
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10. How viral genetic variants and genotypes influence disease and treatment outcome of chronic hepatitis B. Time for an individualised approach?

Author

Rajoriya N, Combet C, Zoulim F, and Janssen HLA

Subjects
Antiviral Agents therapeutic use, Carcinoma, Hepatocellular etiology, Drug Resistance, Viral, Genetic Variation, Genome, Viral, Genotype, Hepatitis B, Chronic complications, Hepatitis B, Chronic virology, Humans, Liver Neoplasms etiology, Treatment Outcome, Hepatitis B virus genetics, Hepatitis B, Chronic drug therapy
Abstract

Chronic hepatitis B virus (HBV) infection remains a global problem. Several HBV genotypes exist with different biology and geographical prevalence. Whilst the future aim of HBV treatment remains viral eradication, current treatment strategies aim to suppress the virus and prevent the progression of liver disease. Current strategies also involve identification of patients for treatment, namely those at risk of progressive liver disease. Identification of HBV genotype, HBV mutants and other predictive factors allow for tailoured treatments, and risk-surveillance pathways, such as hepatocellular cancer screening. In the future, these factors may enable stratification not only of treatment decisions, but also of patients at risk of higher relapse rates when current therapies are discontinued. Newer technologies, such as next-generation sequencing, to assess drug-resistant or immune escape variants and quasi-species heterogeneity in patients, may allow for more information-based treatment decisions between the clinician and the patient. This article serves to discuss how HBV genotypes and genetic variants impact not only upon the disease course and outcomes, but also current treatment strategies. Adopting a personalised genotypic approach may play a role in future strategies to combat the disease. Herein, we discuss new technologies that may allow more informed decision-making for response guided therapy in the battle against HBV., (Copyright © 2017 European Association for the Study of the Liver. All rights reserved.)

Published
2017
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