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Your search keyword '"Santos, Beatriz"' showing total 7 results
Start Over Author "Santos, Beatriz" Language english Journal journal of hepatology
7 results on '"Santos, Beatriz"'

1. THU-210 Dysfunctional activation of the DNA damage response is associated with MASLD progression through an E2F2-dependent mechanism.

Author

Santos, Beatriz Gómez, Fernández-Puertas, Idoia, Gomez-Jauregui, Paul, Sainz-Ramírez, Natalia, Alfaro-Jiménez, Kendall, Castillero, Estibaliz, Nieva-Zuluaga, Ane, Apodaka-Biguri, Maider, Aurrekoetxea, Igor, Delgado, Igotz, Lopategi, Aritz, Iglesias, Ainhoa, González, Lorena Mosteiro, Olartekoetxea, Gaizka Errazti, Gaztambide, Sonia, González, Luis A. Castaño, Bujanda, Luis, Banales, Jesus Maria, Buque, Xabier, and Zubiaga, Ana

Published
2024
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2. FRI-343-YI APAP induced liver damage is prevented by activation of PPARgamma and PPAR-alpha.

Author

Gomez-Jauregui, Paul, Gonzalez-Romero, Francisco, Santos, Beatriz Gómez, Apodaka-Biguri, Maider, Buque, Xabier, Crespo, Maria, Mora, Alfonso, Mesquita, Mariana, Aurrekoetxea, Igor, Delgado, Igotz, Nieva-Zuluaga, Ane, de Gauna, Mikel Ruiz, Fernández-Puertas, Idoia, Sainz-Ramírez, Natalia, Alfaro-Jiménez, Kendall, Irizar, María Esther, Iglesias, Ainhoa, Cubero, Francisco Javier, Sabio, Guadalupe, and Zubiaga, Ana

Published
2024
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3. FRI-472-YI Mitochondrial metabolism is disrupted by ciprofloxacin preventing cholangiocarcinoma cell proliferation.

Author

de Gauna, Mikel Ruiz, Alfaro-Jiménez, Kendall, Nieva-Zuluaga, Ane, Apodaka-Biguri, Maider, Markaide, Enara, Izquierdo-Sánchez, Laura, Rae, Colin, González-Romero, Francisco, Gomez-Jauregui, Paul, Sainz-Ramírez, Natalia, Santos, Beatriz Gómez, Buque, Xabier, Aurrekoetxea, Igor, Delgado, Igotz, Fernández-Puertas, Idoia, Iglesias, Ainhoa, Rourke, Colm O., Rodrigues, Pedro Miguel, Andersen, Jesper, and Calvisi, Diego

Published
2024
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4. Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH.

Author

Simón, Jorge, Goikoetxea-Usandizaga, Naroa, Serrano-Maciá, Marina, Fernández-Ramos, David, Sáenz de Urturi, Diego, Gruskos, Jessica J., Fernández-Tussy, Pablo, Lachiondo-Ortega, Sofía, González-Recio, Irene, Rodríguez-Agudo, Rubén, Gutiérrez-de-Juan, Virginia, Rodríguez-Iruretagoyena, Begoña, Varela-Rey, Marta, Gimenez-Mascarell, Paula, Mercado-Gomez, María, Gómez-Santos, Beatriz, Fernandez-Rodriguez, Carmen, Lopitz-Otsoa, Fernando, Bizkarguenaga, Maider, and Dames, Sibylle

Subjects
*NON-alcoholic fatty liver disease, *MAGNESIUM, *CYCLINS, *CELL physiology, *TRIGLYCERIDES
Abstract

Perturbations of intracellular magnesium (Mg2+) homeostasis have implications for cell physiology. The cyclin M family, CNNM, perform key functions in the transport of Mg2+ across cell membranes. Herein, we aimed to elucidate the role of CNNM4 in the development of non-alcoholic steatohepatitis (NASH). Serum Mg2+ levels and hepatic CNNM4 expression were characterised in clinical samples. Primary hepatocytes were cultured under methionine and choline deprivation. A 0.1% methionine and choline-deficient diet, or a choline-deficient high-fat diet were used to induce NASH in our in vivo rodent models. Cnnm4 was silenced using siRNA, in vitro with DharmaFECT and in vivo with Invivofectamine® or conjugated to N-acetylgalactosamine. Patients with NASH showed hepatic CNNM4 overexpression and dysregulated Mg2+ levels in the serum. Cnnm4 silencing ameliorated hepatic lipid accumulation, inflammation and fibrosis in the rodent NASH models. Mechanistically, CNNM4 knockdown in hepatocytes induced cellular Mg2+ accumulation, reduced endoplasmic reticulum stress, and increased microsomal triglyceride transfer activity, which promoted hepatic lipid clearance by increasing the secretion of VLDLs. CNNM4 is overexpressed in patients with NASH and is responsible for dysregulated Mg2+ transport. Hepatic CNNM4 is a promising therapeutic target for the treatment of NASH. Cyclin M4 (CNNM4) is overexpressed in non-alcoholic steatohepatitis (NASH) and promotes the export of magnesium from the liver. The liver-specific silencing of Cnnm4 ameliorates NASH by reducing endoplasmic reticulum stress and promoting the activity of microsomal triglyceride transfer protein. [Display omitted] • CNNM4 acts as a magnesium exporter in the liver. Its upregulation in NASH leads to elevated magnesium levels in serum. • Liver-specific CNNM4 targeting alleviates steatosis, inflammation, and fibrosis in preclinical NASH models. • siRNA-mediated CNNM4 downregulation promotes hepatic magnesium accumulation and reduces endoplasmic reticulum stress. • Silencing CNNM4 enhances microsomal triglyceride transfer protein activity leading to VLDL assembly and secretion. [ABSTRACT FROM AUTHOR]

Published
2021
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5. FRI-294-Mitochondrial GNMT-complex II is recovered by miR-873-5p targeting in NAFLD.

Author

Ramos, David Fernández, Tussy, Pablo Fernández, Otsoa, Fernando Lopitz, Simón, Jorge, Torres, Lucía Barbier, Santos, Beatriz Gómez, Núñez, Maitane, Azkargorta, Mikel, de Juan, Virginia Gutiérrez, Serrano-Macia, Marina, Agudo, Rubén Rodríguez, Champagne, Devin G., Iruzubieta, Paula, Anguita, Juan, Rincón, Mercedes, Elortza, Felix, Anita, Arslanow, Krawczyk, Marcin, Lammert, Frank, and Kirchmeyer, Melanie

Subjects
*FATTY liver
Published
2019
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6. PS-015-Role of methylation-controlled J-protein, endogenous repressor of the mitochondrial respiratory chain, in cholestatic liver disease.

Author

Iruzubieta, Paula, Barbier-Torres, Lucía, Goikoetxea, Naroa, Delgado, Teresa Cardoso, Ramos, David Fernández, Varela-Rey, Marta, Juan, Virginia Gutiérrez de, Tussy, Pablo Fernández, Zubiete-Franco, Imanol, Simón, Jorge, Congregado, Daniela Mestre, Otsoa, Fernando Lopitz, Santos, Beatriz Gómez, Buque, Xabier, López-Hoyos, Marcos, Apichueta, Patricia, Mato, José M., Anguita, Juan, Rincón, Mercedes, and Crespo, Javier

Subjects
*LIVER diseases, *MITOCHONDRIAL membranes, *BILE ducts, *THERAPEUTICS, *DEOXYCHOLIC acid
Published
2019
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7. PS-008-E2F2 mediated repression of fatty acid B-oxidation is mitigated through CREB1 in progressive non-alcoholic fatty liver disease.

Author

Gonzalez-Romero, Francisco, Mestre, Daniela, Aurrekoetxea, Igor, Urturi, Diego Sáenz de, Gomez-Santos, Beatriz, Nuñez-García, Maitane, Buqué, Xabier, Delgado, Igotz, Palomo-Irigoyen, Marta, Tamayo-Caro, Miguel, Woodhoo, Ashwin, Varela-Rey, Marta, Martínez-Chantar, María Luz, Iglesias, Ainhoa, Lee, Richard, Bhanot, Sanjay, Zubiaga, Ana, and Aspichueta, Patricia

Subjects
*FATTY liver, *FATTY acids
Published
2019
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