1. An algorithmic approach to the management of peripheral nerve tumours.
- Author
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Hems T, Parafioriti A, Thomas BP, and Di Bernardo A
- Subjects
- Humans, Magnetic Resonance Imaging, Nerve Sheath Neoplasms diagnosis, Nerve Sheath Neoplasms pathology, Nerve Sheath Neoplasms surgery, Nerve Sheath Neoplasms therapy, Neurilemmoma diagnosis, Neurilemmoma pathology, Neurilemmoma surgery, Neurilemmoma therapy, Neurofibroma diagnosis, Neurofibroma pathology, Neurofibroma surgery, Neurofibroma therapy, Algorithms, Peripheral Nervous System Neoplasms diagnosis, Peripheral Nervous System Neoplasms pathology, Peripheral Nervous System Neoplasms surgery, Peripheral Nervous System Neoplasms therapy
- Abstract
This article reviews the pathology and management of peripheral nerve tumours, including a framework for investigation and decision-making. Most tumours are benign, including schwannomas and neurofibromas, but malignant peripheral nerve sheath tumours can occur. The risk of malignant change is remote for schwannomas but higher for neurofibromas, particularly in neurofibromatosis type 1. Magnetic resonance imaging is useful for defining the relationship of a swelling with adjacent nerves but is not definitive for tissue diagnosis. Increasing size, pain and neurological deficit suggest malignant change and TruCut needle biopsy is indicated, although there is a risk of sampling error. Excision biopsy preserving nerve function may be carried out for benign tumours to relieve symptoms. Malignant tumours require a multidisciplinary approach. Complete surgical excision with clear margins is the only curative treatment and may be supplemented with radiotherapy and chemotherapy. However, prognosis remains poor, particularly for patients with neurofibromatosis., Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
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