1. The NEIGHBOR Consortium Primary Open-Angle Glaucoma Genome-wide Association Study
- Author
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Wiggs, Janey L, Hauser, Michael A, Abdrabou, Wael, Allingham, Robert Rand, Budenz, Donald L, DelBono, Elizabeth, Friedman, David S, Kang, Jae H, Gaasterland, Douglas, Gaasterland, Terry, Lee, Richard K, Lichter, Paul R, Loomis, Stephanie, Liu, Yutao, McCarty, Cathy, Medeiros, Felipe A, Moroi, Sayoko E, Olson, Lana M, Realini, Anthony, Richards, Julia E, Rozsa, Frank W, Schuman, Joel S, Singh, Kuldev, Stein, Joshua D, Vollrath, Douglas, Weinreb, Robert N, Wollstein, Gadi, Yaspan, Brian L, Yoneyama, Sachiko, Zack, Don, Zhang, Kang, Pericak-Vance, Margaret, Pasquale, Louis R, and Haines, Jonathan L
- Subjects
Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Human Genome ,Eye Disease and Disorders of Vision ,Aging ,Genetics ,Neurosciences ,Neurodegenerative ,Adult ,Aged ,Aged ,80 and over ,Antihypertensive Agents ,Case-Control Studies ,Cooperative Behavior ,Female ,Gene Expression Profiling ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Genotype ,Glaucoma ,Open-Angle ,Humans ,Intraocular Pressure ,Male ,Middle Aged ,Research Design ,Trabeculectomy ,primary open-angle glaucoma ,genome-wide association study ,genetics ,Clinical Sciences ,Ophthalmology & Optometry ,Ophthalmology and optometry - Abstract
Primary open-angle glaucoma (POAG) is a common disease with complex inheritance. The identification of genes predisposing to POAG is an important step toward the development of novel gene-based methods of diagnosis and treatment. Genome-wide association studies (GWAS) have successfully identified genes contributing to complex traits such as POAG however, such studies frequently require very large sample sizes, and thus, collaborations and consortia have been of critical importance for the GWAS approach. In this report we describe the formation of the NEIGHBOR consortium, the harmonized case control definitions used for a POAG GWAS, the clinical features of the cases and controls, and the rationale for the GWAS study design.
- Published
- 2013