1. Determinants of cross-sectional and longitudinal health-related quality of life in memory clinic patients without dementia
- Author
-
Pauline Aalten, Frans R.J. Verhey, Saskia M. Oosterveld, Yolande A.L. Pijnenburg, René J. F. Melis, Claire A. G. Wolfs, Marjolein E. de Vugt, Pieter Jelle Visser, Wiesje M. van der Flier, Eveline P. C. J. Janssen, Philip Scheltens, Sebastian Köhler, Leonie C.P. Banning, Ted Koene, Renske E.G. Hamel, Inez H.G.B. Ramakers, Marcel G. M. Olde Rikkert, Roy P. C. Kessels, Promovendi MHN, Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA Niet Med Staf Psychologie (9), MUMC+: MA Med Staf Spec Psychiatrie (9), Neurology, Amsterdam Neuroscience - Neurodegeneration, Medical psychology, Epidemiology and Data Science, APH - Personalized Medicine, and APH - Methodology
- Subjects
Gerontology ,PARTICIPANTS AGED 24-81 ,Male ,Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1] ,NORMATIVE DATA ,somatic comorbidities ,cognitive functioning ,Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] ,Cohort Studies ,Quality of life (healthcare) ,All institutes and research themes of the Radboud University Medical Center ,mild cognitive impairment ,PEOPLE ,medicine ,Ambulatory Care ,Dementia ,Humans ,Cognitive skill ,FUNCTIONAL GASTROINTESTINAL DISORDERS ,Longitudinal Studies ,OLDER-ADULTS ,ALZHEIMER-DISEASE ,Aged ,Health related quality of life ,Neuro- en revalidatiepsychologie ,business.industry ,Memory clinic ,Neuropsychology and rehabilitation psychology ,EDUCATION ,Original Articles ,medicine.disease ,humanities ,health-related quality of life ,Psychiatry and Mental health ,Cross-Sectional Studies ,Mental Health ,Quality of Life ,Normative ,Female ,neuropsychiatric symptoms ,Neurology (clinical) ,Geriatrics and Gerontology ,Alzheimer's disease ,subjective cognitive decline ,business ,FOLLOW-UP - Abstract
Objective: To identify determinants within 3 different domains (ie, somatic comorbidities, cognitive functioning, and neuropsychiatric symptoms [NPS]) of health-related quality of life (HRQoL) over time in memory clinic patients without dementia. Methods: This longitudinal multicenter cohort study with a 3-year observation period recruited 315 individuals (age: 69.8 ± 8.6, 64.4% males, Mini-Mental State Examination score 26.9 ± 2.6). A multivariable explanatory model was built using linear mixed effects models (forward selection per domain) to select determinants for self-perceived HRQoL over time, as measured by the EuroQoL-5D visual analogue scale (EQ VAS). Results: Mean HRQoL at study entry was 69.4 ± 15.6. The presence of agitation, appetite and eating abnormalities, and eyes/ears/nose (ie, sensory impairment) comorbidities were associated with a change in HRQoL over time. Agitation was most strongly associated with HRQoL over time. Conclusions: The association of somatic comorbidities and NPS in memory clinic patients with course of HRQoL shows that these should receive more awareness, detection, and monitoring by clinicians.
- Published
- 2020
- Full Text
- View/download PDF