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This paper utilizes a fine scale parameterization scheme based on strain spectra and characterizes the temporal and spatial distributions of diapycnal turbulent mixing in the West Pacific Warm Pool. We use Array for Real‐Time Geostrophic Oceanography (Argo) profiles from 2011 to 2022 to generate the turbulent dissipation rate (ε) as a representative of internal‐wave‐induced mixing. We then discuss the influence of El Niño‐Southern Oscillation (ENSO) on turbulent mixing by considering seafloor topography, thermocline depth, and ENSO phases. Results indicate that ENSO can influence the vertical stratification in the ocean by changing the depth of the thermocline, causing the change of interaction between internal tides and seafloor topography, thereby affecting the intensity and vertical distribution of diapycnal turbulent mixing. During La Niña years, the value of ε is larger compared to that of El Niño years. Compared to rough regions, the thermocline variations induced by ENSO have a more pronounced impact in the smooth regions. The variability in turbulent mixing influenced by ENSO is crucial for heat and substance exchange in the equatorial Pacific. [ABSTRACT FROM AUTHOR]