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Your search keyword '"Fouchier, Ron"' showing total 23 results
Start Over Author "Fouchier, Ron" Journal journal of general virology
23 results on '"Fouchier, Ron"'

5. Influenza A virus evolution and spatio-temporal dynamics in Eurasian wild birds: a phylogenetic and phylogeographical study of whole-genome sequence data

Author

Lewis, Nicola S., primary, Verhagen, Josanne H., additional, Javakhishvili, Zurab, additional, Russell, Colin A., additional, Lexmond, Pascal, additional, Westgeest, Kim B., additional, Bestebroer, Theo M., additional, Halpin, Rebecca A., additional, Lin, Xudong, additional, Ransier, Amy, additional, Fedorova, Nadia B., additional, Stockwell, Timothy B., additional, Latorre-Margalef, Neus, additional, Olsen, Björn, additional, Smith, Gavin, additional, Bahl, Justin, additional, Wentworth, David E., additional, Waldenström, Jonas, additional, Fouchier, Ron A. M., additional, and de Graaf, Miranda, additional

Published
2015
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8. Genetic evolution of the neuraminidase of influenza A (H3N2) viruses from 1968 to 2009 and its correspondence to haemagglutinin evolution

Author

Westgeest, Kim B., primary, de Graaf, Miranda, additional, Fourment, Mathieu, additional, Bestebroer, Theo M., additional, van Beek, Ruud, additional, Spronken, Monique I. J., additional, de Jong, Jan C., additional, Rimmelzwaan, Guus F., additional, Russell, Colin A., additional, Osterhaus, Albert D. M. E., additional, Smith, Gavin J. D., additional, Smith, Derek J., additional, and Fouchier, Ron A. M., additional

Published
2012
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9. Cross-protective immunity against influenza pH1N1 2009 viruses induced by seasonal influenza A (H3N2) virus is mediated by virus-specific T-cells

Author

Hillaire, Marine L. B., primary, van Trierum, Stella E., additional, Kreijtz, Joost H. C. M., additional, Bodewes, Rogier, additional, Geelhoed-Mieras, Martina M., additional, Nieuwkoop, Nella J., additional, Fouchier, Ron A. M., additional, Kuiken, Thijs, additional, Osterhaus, Albert D. M. E, additional, and Rimmelzwaan, Guus F., additional

Published
2011
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16. Immunization of Syrian golden hamsters with F subunit vaccine of human metapneumovirus induces protection against challenge with homologous or heterologous strains

Author

Herfst, Sander, primary, de Graaf, Miranda, additional, Schrauwen, Eefje J. A., additional, Ulbrandt, Nancy D., additional, Barnes, Arnita S., additional, Senthil, Kannaki, additional, Osterhaus, Albert D. M. E., additional, Fouchier, Ron A. M., additional, and van den Hoogen, Bernadette G., additional

Published
2007
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19. Identification of small-animal and primate models for evaluation of vaccine candidates for human metapneumovirus (hMPV) and implications for hMPV vaccine design

Author

MacPhail, Mia, primary, Schickli, Jeanne H., additional, Tang, Roderick S., additional, Kaur, Jasmine, additional, Robinson, Christopher, additional, Fouchier, Ron A. M., additional, Osterhaus, Albert D. M. E., additional, Spaete, Richard R., additional, and Haller, Aurelia A., additional

Published
2004
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20. ICTV Virus Taxonomy Profile: Paramyxoviridae .

Author

Rima B, Balkema-Buschmann A, Dundon WG, Duprex P, Easton A, Fouchier R, Kurath G, Lamb R, Lee B, Rota P, Wang L, and Ictv Report Consortium

Subjects
Databases, Factual, Humans, Paramyxoviridae physiology, Paramyxoviridae ultrastructure, Web Browser, DNA Barcoding, Taxonomic methods, Paramyxoviridae classification, Paramyxoviridae genetics
Abstract

The family Paramyxoviridae consists of large enveloped RNA viruses infecting mammals, birds, reptiles and fish. Many paramyxoviruses are host-specific and several, such as measles virus, mumps virus, Nipah virus, Hendra virus and several parainfluenza viruses, are pathogenic for humans. The transmission of paramyxoviruses is horizontal, mainly through airborne routes; no vectors are known. This is a summary of the current International Committee on Taxonomy of Viruses (ICTV) Report on the family Paramyxoviridae . which is available at ictv.global/report/paramyxoviridae.

Published
2019
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21. ICTV Virus Taxonomy Profile: Pneumoviridae.

Author

Rima B, Collins P, Easton A, Fouchier R, Kurath G, Lamb RA, Lee B, Maisner A, Rota P, Wang L, and Ictv Report Consortium

Subjects
Animals, Birds virology, Humans, Mammals virology, RNA Viruses genetics, RNA Viruses isolation & purification, Virus Replication, RNA Virus Infections veterinary, RNA Virus Infections virology, RNA Viruses classification
Abstract

The family Pneumoviridae comprises large enveloped negative-sense RNA viruses. This taxon was formerly a subfamily within the Paramyxoviridae, but was reclassified in 2016 as a family with two genera, Orthopneumovirus and Metapneumovirus. Pneumoviruses infect a range of mammalian species, while some members of the Metapneumovirus genus may also infect birds. Some viruses are specific and pathogenic for humans, such as human respiratory syncytial virus and human metapneumovirus. There are no known vectors for pneumoviruses and transmission is thought to be primarily by aerosol droplets and contact. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of the Pneumoviridae, which is available at www.ictv.global/report/pneumoviridae.

Published
2017
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22. Evaluation of a modified vaccinia virus Ankara (MVA)-based candidate pandemic influenza A/H1N1 vaccine in the ferret model.

Author

Kreijtz JH, Süzer Y, Bodewes R, Schwantes A, van Amerongen G, Verburgh RJ, de Mutsert G, van den Brand J, van Trierum SE, Kuiken T, Fouchier RA, Osterhaus AD, Sutter G, and Rimmelzwaan GF

Subjects
Animals, Antibodies, Viral blood, Body Weight, Female, Ferrets, Fever prevention & control, Hemagglutinins, Viral genetics, Hemagglutinins, Viral immunology, Histocytochemistry, Immunization, Secondary methods, Influenza A Virus, H1N1 Subtype genetics, Influenza Vaccines genetics, Lung pathology, Microscopy, Orthomyxoviridae Infections pathology, Orthomyxoviridae Infections prevention & control, Vaccines, Synthetic genetics, Vaccines, Synthetic immunology, Viral Load, Genetic Vectors, Influenza A Virus, H1N1 Subtype immunology, Influenza Vaccines immunology, Vaccinia virus genetics
Abstract

The zoonotic transmissions of highly pathogenic avian influenza viruses of the H5N1 subtype that have occurred since 1997 have sparked the development of novel influenza vaccines. The advent of reverse genetics technology, cell-culture production techniques and novel adjuvants has improved the vaccine strain preparation, production process and immunogenicity of the vaccines, respectively, and has accelerated the availability of pandemic influenza vaccines. However, there is still room for improvement, and alternative vaccine preparations can be explored, such as viral vectors. Modified vaccinia virus Ankara (MVA), originally developed as a safe smallpox vaccine, can be exploited as a viral vector and has many favourable properties. Recently, we have demonstrated that an MVA-based vaccine could protect mice and macaques against infection with highly pathogenic influenza viruses of the H5N1 subtype. In the present study, recombinant MVA expressing the haemagglutinin (HA) gene of pandemic influenza A/H1N1 virus was evaluated in the ferret model. A single immunization induced modest antibody responses and afforded only modest protection against the development of severe disease upon infection with a 2009(H1N1) strain. In contrast, two immunizations induced robust antibody responses and protected ferrets from developing severe disease, confirming that MVA is an attractive influenza vaccine production platform.

Published
2010
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23. Vaccination with whole inactivated virus vaccine affects the induction of heterosubtypic immunity against influenza virus A/H5N1 and immunodominance of virus-specific CD8+ T-cell responses in mice.

Author

Bodewes R, Kreijtz JH, Hillaire ML, Geelhoed-Mieras MM, Fouchier RA, Osterhaus AD, and Rimmelzwaan GF

Subjects
Animals, Antibodies, Viral blood, Antibodies, Viral immunology, Antibody Specificity, Female, Immunodominant Epitopes, Influenza A Virus, H3N2 Subtype immunology, Interferon-gamma, Lung cytology, Lung virology, Mice, Mice, Inbred C57BL, Specific Pathogen-Free Organisms, Spleen cytology, Spleen virology, Vaccination, CD8-Positive T-Lymphocytes physiology, Influenza A Virus, H5N1 Subtype immunology, Influenza Vaccines immunology
Abstract

It was recently shown that the use of an experimental subunit vaccine protected mice against infection with a human A/H3N2 influenza virus, but consequently affected the induction of heterosubtypic immunity to a highly pathogenic A/H5N1 influenza virus, which was otherwise induced by the A/H3N2 infection. As whole inactivated virus (WIV) vaccines are widely used to protect against seasonal influenza and also contain inner viral proteins such as the nucleoprotein (NP), the potential of a WIV vaccine to induce protective immunity against infection was tested with a homologous A/H3N2 (A/Hong Kong/2/68) and a heterosubtypic A/H5N1 influenza virus (A/Indonesia/5/05). As expected, the vaccine afforded protection against infection with the A/H3N2 virus only. In addition, it was demonstrated that the use of WIV vaccine for protection against A/H3N2 infection affected the induction of heterosubtypic immunity that was otherwise afforded by A/H3N2 influenza virus infection. The reduction in protective immunity correlated with changes in the immunodominance patterns of the CD8(+) T-cell responses directed to the epitopes located in the acid polymerase subunit of the viral RNA polymerase (PA(224-233)) and the NP (NP(366-374)). In unvaccinated mice that experienced infection with the A/H3N2 influenza virus, the magnitude of the CD8(+) T-cell response to both peptides was similar on secondary infection with A/H5N1 influenza virus. In contrast, prior vaccination with WIV affected the immunodominance pattern and skewed the response after infection with influenza virus A/Indonesia/5/05 towards a dominant NP(366-374)-specific response. These findings may have implications for vaccination strategies aimed at the induction of protective immunity to seasonal and/or pandemic influenza.

Published
2010
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