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Background: After binding to their corresponding receptors, cytokines mediate a variety of biological activities. However, the activity of cytokines in dental pulp has not been studied at the single cell level. Methods: The cytokines activity of dental pulp was analyzed through CytoSig with the single cell sequencing data of dental pulp. Results: In total, 43 cytokine signalling pathways were analyzed with CytoSig. The activity of TRAIL, NO, IL3, CXCL12 and IL1A was high in the majority of cells in dental pulp. NO, TRAIL, CXCL12, BMP4 and BMP6 had higher activity in dental pulp stem cells, whereas CXCL12, BMP4, BMP6, BMP2 and IFN1 were the cytokines with high activity in pulp cells. Conclusions: Our findings show the landscape of cytokine activity in dental pulp. [ABSTRACT FROM AUTHOR]