7 results on '"Turaga KK"'
Search Results
2. Survival in Total Preoperative vs. Perioperative Chemotherapy for Patients with Metastatic High-Grade Appendiceal Adenocarcinoma Undergoing CRS/HIPEC.
- Author
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Morgan RB, Yan A, Dhiman A, Shergill A, Polite B, Turaga KK, and Eng OS
- Subjects
- Humans, Hyperthermic Intraperitoneal Chemotherapy, Cytoreduction Surgical Procedures adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Retrospective Studies, Survival Rate, Combined Modality Therapy, Appendiceal Neoplasms, Adenocarcinoma pathology, Hyperthermia, Induced adverse effects
- Published
- 2022
- Full Text
- View/download PDF
3. Peritoneal Metastases in Colorectal Cancer: Biology and Barriers.
- Author
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Xue L, Hyman NH, Turaga KK, and Eng OS
- Subjects
- Combined Modality Therapy, Cytoreduction Surgical Procedures, Humans, Peritoneum, Colorectal Neoplasms therapy, Hyperthermia, Induced, Peritoneal Neoplasms therapy
- Abstract
Background: Advances in the molecular biology of tumor metastasis have paralleled the evolution in the management of metastatic disease from colorectal cancer. In this review, we summarize the current understanding of the mechanism of colorectal cancer metastases, in particular that of peritoneal metastases, as well as clinical data on the treatment of this disease., Methods: A review of relevant English literature using MEDLINE/PubMed on the biology of colorectal cancer metastases, determinants of oligometastasis, and use of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the treatment of metastatic colorectal cancer is presented., Results: Recognition of oligometastasis in the evolution of colorectal peritoneal metastases provides the theoretical framework for which cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy is considered. Clearly, a subset of patients benefit from peritoneal metastasectomy., Conclusion: Advances in cancer biology and clinical imaging promise to expand the role of cytoreductive surgery with or without intraperitoneal chemotherapy in the management of peritoneal metastases from colorectal cancer.
- Published
- 2020
- Full Text
- View/download PDF
4. Modern Surgical Techniques in Cytoreductive Surgery.
- Author
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Izquierdo F, Sherman SK, Schuitevoerder D, and Turaga KK
- Published
- 2020
- Full Text
- View/download PDF
5. Patency rates of portal vein/superior mesenteric vein reconstruction after pancreatectomy for pancreatic cancer.
- Author
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Krepline AN, Christians KK, Duelge K, Mahmoud A, Ritch P, George B, Erickson BA, Foley WD, Quebbeman EJ, Turaga KK, Johnston FM, Gamblin TC, Evans DB, and Tsai S
- Subjects
- Aged, Cohort Studies, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Pancreatectomy adverse effects, Pancreatic Neoplasms mortality, Pancreatic Neoplasms pathology, Postoperative Complications mortality, Postoperative Complications physiopathology, Postoperative Complications therapy, Plastic Surgery Procedures methods, Retrospective Studies, Risk Assessment, Survival Analysis, Treatment Outcome, Mesenteric Veins surgery, Pancreatectomy methods, Pancreatic Neoplasms surgery, Portal Vein surgery, Vascular Patency physiology, Vascular Surgical Procedures methods
- Abstract
Background: Pancreatectomy with venous reconstruction (VR) for pancreatic cancer (PC) is occurring more commonly. Few studies have examined the long-term patency of the superior mesenteric-portal vein confluence following reconstruction., Methods: From 2007 to 2013, patients who underwent pancreatic resection with VR for PC were classified by type of reconstruction. Patency of VR was assessed using surveillance computed tomographic imaging obtained from date of surgery to last follow-up., Results: VR was performed in 43 patients and included the following: tangential resection with primary repair (7, 16%) or saphenous vein patch (9, 21%); segmental resection with splenic vein division and either primary anastomosis (10, 23%) or internal jugular vein interposition (8, 19%); or segmental resection with splenic vein preservation and either primary anastomosis (3, 7%) or interposition grafting (6, 14%). All patients were instructed to take aspirin after surgery; low molecular weight heparin was not routinely used. An occluded VR was found in four (9%) of the 43 patients at a median follow-up of 13 months; median time to detection of thrombosis in the four patients was 72 days (range 16-238)., Conclusions: Pancreatectomy with VR can be performed with high patency rates. The optimal postoperative pharmacologic therapy to prevent thrombosis requires further investigation.
- Published
- 2014
- Full Text
- View/download PDF
6. Defining the role of adjuvant external beam radiotherapy on resected adenocarcinoma of the ampulla of vater.
- Author
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Miura JT, Jayakrishnan TT, Amini A, Johnston FM, Tsai S, Erickson B, Quebbeman EJ, Christians KK, Evans DB, Gamblin TC, and Turaga KK
- Subjects
- Adenocarcinoma pathology, Adenocarcinoma surgery, Adult, Aged, Ampulla of Vater pathology, Ampulla of Vater surgery, Cohort Studies, Common Bile Duct Neoplasms mortality, Common Bile Duct Neoplasms pathology, Common Bile Duct Neoplasms surgery, Confidence Intervals, Disease-Free Survival, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Multivariate Analysis, Neoplasm Recurrence, Local mortality, Neoplasm Recurrence, Local therapy, Propensity Score, Radiotherapy, Adjuvant methods, Retrospective Studies, Role, SEER Program, Survival Analysis, Treatment Outcome, Young Adult, Adenocarcinoma mortality, Adenocarcinoma radiotherapy, Ampulla of Vater radiation effects, Common Bile Duct Neoplasms radiotherapy, Neoplasm Recurrence, Local pathology
- Abstract
The role of adjuvant radiotherapy in the treatment of ampullary carcinoma (AC) remains unclear. We hypothesized that adjuvant radiotherapy (RT) does not improve survival following resection for AC. The SEER database was queried for patients with non-metastatic AC who underwent surgery (S) from 2004 to 2010. Propensity score (PS) modeling was applied to create balanced cohorts of patients that would be equally likely to receive RT. Cox proportional hazard models were used to compare survival. Of 1,287 patients, 329 (25.6%) received adjuvant RT. Unadjusted median overall survival (OS) for patients receiving adjuvant RT compared to S alone was 27 vs. 36 months (p = 0.14). Patients receiving RT were younger (63 vs. 69 years, p < 0.001), had more advanced tumors (69 vs. 53% T3/T4, p < 0.001), and had more frequent lymph node metastasis (73 vs. 40%, p < 0.001). Adjuvant RT failed to improve both overall survival (27 vs. 29 months, p = 0.58) and disease-specific survival (36 vs. 40 months, p = 0.92) in propensity-matched cohorts, although certain imbalances remained between treatment groups. Adjuvant RT does not confer a survival benefit for patients with ampullary tumors. The lack of disease-specific survival benefit suggests that it may also not be beneficial to prevent local recurrences.
- Published
- 2014
- Full Text
- View/download PDF
7. Assessment of diaphragmatic stressors as risk factors for symptomatic failure of laparoscopic nissen fundoplication.
- Author
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Iqbal A, Kakarlapudi GV, Awad ZT, Haynatzki G, Turaga KK, Karu A, Fritz K, Haider M, Mittal SK, and Filipi CJ
- Subjects
- Adolescent, Adult, Aged, Antidepressive Agents therapeutic use, Body Height physiology, Body Mass Index, Case-Control Studies, Cough physiopathology, Eructation physiopathology, Esophagitis physiopathology, Female, Follow-Up Studies, Gagging physiology, Hernia, Hiatal complications, Hiccup physiopathology, Humans, Male, Middle Aged, Motion Sickness physiopathology, Postoperative Nausea and Vomiting etiology, Retrospective Studies, Risk Factors, Smoking physiopathology, Treatment Failure, Diaphragm physiopathology, Fundoplication methods, Gastroesophageal Reflux surgery, Laparoscopy methods
- Abstract
An important limitation of antireflux surgery is a 5%-10% failure rate. We investigated the correlation between various diaphragm stressors and failure of antireflux surgery. Forty-one study cases who underwent a reoperative antireflux operation from 1997 to 2001 and 50 control patients who had undergone a successful laparoscopic Nissen fundoplication during the same period without clinical or symptomatic evidence of failure were randomly selected for comparison. A retrospective analysis was conducted utilizing a standardized diaphragm stressor questionnaire, addressing the period between the primary and secondary operation. Stressors considered in the study included height, body mass index (BMI), postoperative gagging, vomiting, weight lifting (greater than 100 pounds), coughing, hiccuping, motion sickness, retching, belching, antidepressant use, smoking, preoperative grade of esophagitis, size of hiatal hernia, lower esophageal sphincter pressure, esophageal body pressures, and preoperative response to proton pump inhibitors. Of the potential stressors investigated, the following were significantly associated with surgical failure after adjusting for other variables through multivariate analysis: gagging (P = 0.005), belching (P = 0.02), and hernia size greater than 3 cm (P = 0.04; Table 1). Other potential risk factors show trends as obvious in Fig. 2. Vomiting was significant (P = 0.01) in the earlier models but lost significance when logistic regression was applied. Patients with postoperative gagging and an intraoperative hiatal hernia (greater than 3 cm) have a poorer outcome, whereas patients with postoperative belching have a better long-term outcome.
- Published
- 2006
- Full Text
- View/download PDF
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