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Your search keyword '"Ming-Yan Cai"' showing total 3 results
Start Over Author "Ming-Yan Cai" Journal journal of gastroenterology
3 results on '"Ming-Yan Cai"'

1. Short-term safety and efficacy of peroral endoscopic myotomy for the treatment of achalasia in children

Author

Mei-Dong Xu, Yun-Shi Zhong, Li-Qing Yao, Ying Huang, Wen-Zheng Qin, Ying Fang, Ping-Hong Zhou, Shiyao Chen, Jian-Wei Hu, Ming-Yan Cai, Yi-Qun Zhang, Xiaoxia Ren, Wei-Feng Chen, Quan-Lin Li, Yun Wang, Zuqiang Liu, and Hongbin Yang

Subjects
Myotomy, Adult, Male, Natural Orifice Endoscopic Surgery, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Operative Time, Achalasia, Heller Myotomy, Esophageal Sphincter, Lower, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Treatment Failure, Adverse effect, Child, Retrospective Studies, business.industry, Gastroenterology, Infant, Perioperative, Length of Stay, medicine.disease, Confidence interval, Colorectal surgery, Surgery, Esophageal Achalasia, Pneumothorax, 030220 oncology & carcinogenesis, Child, Preschool, Gastroesophageal Reflux, 030211 gastroenterology & hepatology, Female, Esophagoscopy, business, Abdominal surgery, Follow-Up Studies
Abstract

Peroral endoscopic myotomy (POEM) has shown excellent results for the treatment of achalasia in adults, but studies for children are limited. The study was aimed to analyze outcomes of peroral endoscopic myotomy (POEM) in children and compared with those in adults in a large multi-center study.Records of consecutive patients with achalasia who underwent POEM at three tertiary centers were reviewed. A total of 130 children were included in this study. The primary outcomes of perioperative outcomes and clinical follow-up data were analyzed.One child (0.8%) experienced technical failure. Five children (3.8%) had major adverse events, including one with pneumothorax requiring drainage, two with delayed mucosa barrier failure, one with readmission, and one with vital-sign instability. Both post-POEM Eckardt score and median LES pressure were significantly lower than their pre-POEM reference values in children (0.7 vs 7.4; 7.0 vs 27.1 mmHg; both P 0.001). During a median follow-up time of 40 months, clinical reflux rate was 27.0% and clinical failure rates at 1, 3, and 5 years were 1.8%, 3.5%, and 4.4% for children. The technical failure, major adverse events, and postoperative clinical reflux were comparable between children and adults (all P 0.05). Kaplan-Meier analysis showed that the risk of clinical failure was lower in children than adults (log-rank test, hazard ratio = 0.37, 95% confidence interval 0.15-0.91, P = 0.023).POEM can be safely performed in children with achalasia, and produce a better clinical response during long-term follow-up compared with that in adults.

Published
2019

2. Preoperative serum gamma-glutamyl transferase to alanine aminotransferase ratio is a convenient prognostic marker for Child-Pugh A hepatocellular carcinoma after operation

Author

Jia Fan, Ming-Yan Cai, Yi-Wei Li, Jian Zhou, Qiang Gao, Zhao-You Tang, Shuang-Jian Qiu, and Min-Jie Ju

Subjects
medicine.medical_specialty, Pathology, Carcinoma, Hepatocellular, digestive system, Gastroenterology, Internal medicine, medicine, Carcinoma, Hepatectomy, Humans, Gamma-glutamyltransferase, Survival analysis, Hepatitis, biology, business.industry, Liver Neoplasms, Alanine Transaminase, gamma-Glutamyltransferase, Middle Aged, Hepatology, Hepatitis B, Prognosis, medicine.disease, Survival Analysis, Primary tumor, digestive system diseases, ROC Curve, Hepatocellular carcinoma, biology.protein, Female, Neoplasm Recurrence, Local, business
Abstract

The ratio of serum gamma-glutamyl transferase (GGT) to alanine aminotransferase (ALT) is a parameter for assessing responses to antiviral therapies. The relationship between the prognosis of hepatitis B-associated hepatocellular carcinoma (HCC) and preoperative GGT/ALT is studied in hepatectomized Child-Pugh A patients. Two hundred and nineteen patients with hepatitis B virus-related HCC were included. Serum ALT and GGT levels were examined preoperatively and the GGT/ALT ratios were calculated. Their prognostic capabilities were evaluated by Cox-regression model. As dichotomized variables, GGT and ALT were distributed unequally (P

Published
2009

3. Preoperative serum gamma-glutamyl transferase to alanine aminotransferase ratio is a convenient prognostic marker for Child-Pugh A hepatocellular carcinoma after operation.

Author

Min-Jie Ju, Shuang-Jian Qiu, Jia Fan, Jian Zhou, Qiang Gao, Ming-Yan Cai, Yi-Wei Li, and Zhao-You Tang

Subjects
MEDICAL research, ANTIVIRAL agents, ALANINE aminotransferase, LIVER cancer, LIVER surgery, HEPATITIS B virus, AMINOTRANSFERASES
Abstract

The ratio of serum gamma-glutamyl transferase (GGT) to alanine aminotransferase (ALT) is a parameter for assessing responses to antiviral therapies. The relationship between the prognosis of hepatitis B-associated hepatocellular carcinoma (HCC) and preoperative GGT/ALT is studied in hepatectomized Child-Pugh A patients. Two hundred and nineteen patients with hepatitis B virus-related HCC were included. Serum ALT and GGT levels were examined preoperatively and the GGT/ALT ratios were calculated. Their prognostic capabilities were evaluated by Cox-regression model. As dichotomized variables, GGT and ALT were distributed unequally ( P < 0.001). Most patients had high levels of GGT ( n = 110) but low levels of ALT ( n = 185). ALT displayed no relation to recurrence or survival, while GGT was independently associated with survival ( P = 0.002). The GGT/ALT ratio could predict survival precisely either in a continuous or dichotomized fashion ( P < 0.001 and 0.001, respectively), and also related to recurrence when dichotomized ( P = 0.002). Additionally, high GGT/ALT ratio was associated with high early recurrence rates, more recurrence-related deaths and various aggressive tumor characteristics such as larger tumor size, vascular invasion, poor encapsulation and advanced BCLC stage. In further stratified analyses, this ratio could discriminate the outcomes of patients with high- or low-α-fetoprotein level. The elevated GGT/ALT ratio was a promising predictor for poor prognosis of Child-Pugh A HCC patients after operation mainly through its tight relevance to the primary tumor burden. [ABSTRACT FROM AUTHOR]

Published
2009
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