1. Gastric Adenocarcinoma of Fundic Gland Type with Aggressive Transformation and Lymph Node Metastasis: a Case Report.
- Author
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Yasuhiro Okumura, Manabu Takamatsu, Manabu Ohashi, Yorimasa Yamamoto, Noriko Yamamoto, Hiroshi Kawachi, Satoshi Ida, Koshi Kumagai, Souya Nunobe, Naoki Hiki, and Takeshi Sano
- Subjects
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ENDOSCOPIC ultrasonography , *LYMPH nodes , *LYMPHADENECTOMY , *METASTASIS , *ADENOCARCINOMA - Abstract
A 55-year-old man visited our hospital for a detailed examination of a gastric submucosal tumor that was first detected 10 years prior. The tumor continued to grow and had developed a depressed area in its center. A histopathological examination of biopsy specimens revealed gastric adenocarcinoma of the fundic gland type (GA-FG). It was diagnosed as T2 based on the invasion depth as determined by white-light endoscopy and endoscopic ultrasonography. A total gastrectomy with lymphadenectomy was performed and a GA-FG in the mucosa and submucosa was confirmed histopathologically. However, there was a gradual transition to an infiltrative tubular adenocarcinoma with poorly differentiated components in the muscular and subserosal layers. Metastasis was identified in a dissected lymph node (LN). This is the first report of a GA-FG progressing to an aggressive cancer with LN metastasis. These findings modify our understanding of the pathophysiology of GA-FG. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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