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2 results on '"Mingtong Ye"'

1. Cyanidin-3-O-β-glucoside protects against liver fibrosis induced by alcohol via regulating energy homeostasis and AMPK/autophagy signaling pathway

Author

Ting Wan, Sufan Wang, Mingtong Ye, Wenhua Ling, and Lili Yang

Subjects
Anthocyanins, Energy metabolism, AMPK/autophagy signaling, Nutrition. Foods and food supply, TX341-641
Abstract

Cyanidin-3-O-β-glucoside (Cy-3-G) has protective properties in many diseases. Whether Cy-3-G has protective effects on alcohol induced liver injuries remains uncertain. In our study, mice were fed with a high fat high cholesterol diet (HFC) plus ethanol for 12 weeks. Cy-3-G supplementation reversed the liver damage induced by alcohol. In vitro studies, Cy-3-G restored the intracellular energy status of LX-2 cells and inhibited the activation of LX-2 cells induced by ethanol plus palmitate. The protective effect of Cy-3-G is via the increase of AMPK phosphorylation and autophagy. In conclusion, Cy-3-G ameliorated chronic alcoholic liver injuries, possibly by improving energy metabolic status. Specifically, liver fibrosis was protected by Cy-3-G via inhibiting the activation of stellate cells, which was mediated partially by AMPK/autophagy signaling pathway.

Published
2017
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2. Cyanidin-3-O-β-glucoside protects against liver fibrosis induced by alcohol via regulating energy homeostasis and AMPK/autophagy signaling pathway

Author

Sufan Wang, Wen-Hua Ling, Lili Yang, Ting Wan, and Mingtong Ye

Subjects
0301 basic medicine, medicine.medical_specialty, Medicine (miscellaneous), Biology, Energy homeostasis, Anthocyanins, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, AMPK/autophagy signaling, TX341-641, Nutrition and Dietetics, Ethanol, Nutrition. Foods and food supply, Autophagy, AMPK, Energy metabolism, 030104 developmental biology, Endocrinology, chemistry, 030220 oncology & carcinogenesis, Hepatic stellate cell, Phosphorylation, Signal transduction, Intracellular, Food Science
Abstract

Cyanidin-3-O-β-glucoside (Cy-3-G) has protective properties in many diseases. Whether Cy-3-G has protective effects on alcohol induced liver injuries remains uncertain. In our study, mice were fed with a high fat high cholesterol diet (HFC) plus ethanol for 12 weeks. Cy-3-G supplementation reversed the liver damage induced by alcohol. In vitro studies, Cy-3-G restored the intracellular energy status of LX-2 cells and inhibited the activation of LX-2 cells induced by ethanol plus palmitate. The protective effect of Cy-3-G is via the increase of AMPK phosphorylation and autophagy. In conclusion, Cy-3-G ameliorated chronic alcoholic liver injuries, possibly by improving energy metabolic status. Specifically, liver fibrosis was protected by Cy-3-G via inhibiting the activation of stellate cells, which was mediated partially by AMPK/autophagy signaling pathway.

Published
2017

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