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Start Over Author "Jiyeon Baek" Journal journal of functional foods
2 results on '"Jiyeon Baek"'

1. Selective oncolytic effect in Epstein-Barr virus (EBV)-associated gastric carcinoma through efficient lytic induction by Euphorbia extracts

Author

Dong-eun Kim, Sunhee Jung, Hyung Won Ryu, Miri Choi, Mingu Kang, Hyunju Kang, Heung Joo Yuk, Hyejeong Jeong, Jiyeon Baek, Jae-Hyoung Song, Janghwan Kim, Hyojeung Kang, Sang-Bae Han, Sei-Ryang Oh, and Sungchan Cho

Subjects
Epstein-Barr virus, EBV-associated gastric carcinoma, Lytic induction, Medicinal plant extracts, Euphorbia, Nutrition. Foods and food supply, TX341-641
Abstract

Lytic induction of latent Epstein-Barr virus (EBV) has been considered as a therapeutic approach for efficient treatment of EBV-associated malignancies. Here, we established a robust assay system quantitatively measuring EBV lytic induction and identified three Euphorbia extracts as strong inducers from a screen of Korean medicinal plant extracts library. Expression of lytic genes were efficiently induced by each Euphorbia extract in SNU-719 (EBV-positive gastric carcinoma cells). Euphorbia pekinensis, out of three extracts, exhibited the most potent lytic-inducing activity. Importantly, treatment with E. pekinensis extract led to an obvious cytotoxic effect on SNU-719 cells, but little on MKN-74 cells (EBV-negative gastric carcinoma cells), indicating the selective oncolytic effect on EBV-positive gastric carcinoma. We further revealed that lytic-inducing activity of E. pekinensis was mediated by PKC/MEK signal. Moreover, we defined two structural analogs of PMA with strong lytic-inducing activity, suggesting their therapeutic applicability for the treatment of EBV-associated gastric carcinoma.

Published
2018
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2. Selective oncolytic effect in Epstein-Barr virus (EBV)-associated gastric carcinoma through efficient lytic induction by Euphorbia extracts

Author

Sei-Ryang Oh, Hyojeung Kang, Hyunju Kang, Hyung Won Ryu, Heung Joo Yuk, Jiyeon Baek, Dong-eun Kim, Miri Choi, Janghwan Kim, Hyejeong Jeong, Sungchan Cho, Jae-Hyoung Song, Mingu Kang, Sunhee Jung, and Sang-Bae Han

Subjects
0301 basic medicine, Medicine (miscellaneous), EBV-associated gastric carcinoma, medicine.disease_cause, Virus, 03 medical and health sciences, Euphorbia, hemic and lymphatic diseases, medicine, Carcinoma, Cytotoxic T cell, Epstein-Barr virus, Medicinal plant extracts, TX341-641, Cytotoxicity, Nutrition and Dietetics, biology, Chemistry, Nutrition. Foods and food supply, biology.organism_classification, medicine.disease, Lytic induction, Epstein–Barr virus, Oncolytic virus, 030104 developmental biology, Lytic cycle, Cancer research, Food Science, Euphorbia pekinensis
Abstract

Lytic induction of latent Epstein-Barr virus (EBV) has been considered as a therapeutic approach for efficient treatment of EBV-associated malignancies. Here, we established a robust assay system quantitatively measuring EBV lytic induction and identified three Euphorbia extracts as strong inducers from a screen of Korean medicinal plant extracts library. Expression of lytic genes were efficiently induced by each Euphorbia extract in SNU-719 (EBV-positive gastric carcinoma cells). Euphorbia pekinensis, out of three extracts, exhibited the most potent lytic-inducing activity. Importantly, treatment with E. pekinensis extract led to an obvious cytotoxic effect on SNU-719 cells, but little on MKN-74 cells (EBV-negative gastric carcinoma cells), indicating the selective oncolytic effect on EBV-positive gastric carcinoma. We further revealed that lytic-inducing activity of E. pekinensis was mediated by PKC/MEK signal. Moreover, we defined two structural analogs of PMA with strong lytic-inducing activity, suggesting their therapeutic applicability for the treatment of EBV-associated gastric carcinoma.

Published
2018

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