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This study focusses on the design and scale-up of industrial lactic acid production by fermentation of dairy cheese whey permeate based on standard methodological parameters. The aim was to address the shortcomings of standard scale-up methodologies and provide a framework for fermenter scale-up that enables the accurate estimation of energy consumption by suitable selection of turbine and speed for industrial deployment. Moreover, life cycle assessment (LCA) was carried out to identify the potential impacts and possibilities to reduce the operation associated emissions at an early stage. The findings showed that a 3000 times scale-up strategy assuming constant geometric dimensions and specific energy consumption ( P/V w ) resulted in lower impeller speed and energy demand. The Rushton turbine blade (RTB) and LightninA315 four-blade hydrofoil (LA315) were found to have the highest and lowest torque output, respectively, at a similar P/V w of 2.8 kWm -3 , with agitation speeds of 1.33 and 2.5 s -1 , respectively. RTB demonstrating lower shear damage towards cells (up to 1.33 s -1 ) was selected because it permits high torque, low-power and acceptable turbulence. The LCA results showed a strong relation between the number of impellers installed and associated emissions suggesting a trade-off between mixing performance and environmental impacts., Supplementary Information: The online version contains supplementary material available at 10.1007/s13197-021-05239-6., Competing Interests: Conflict of interestThe authors declare that they have no competing financial interests for this work., (© The Author(s) 2021.)