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Start Over Author "Stoykova, Boyka" Journal journal of fluorine chemistry

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1. N-Hydroxycinnamoyl amides of fluorinated amino acids: Synthesis, anti-tyrosinase and DPPH scavenging activities.

Author

Chochkova, Maya, Stoykova, Boyka, Ivanova, Galya, Ranz, Andreas, Guo, Xinghua, Lankmayr, Ernst, and Milkova, Tsenka

Subjects
*CINNAMOYL compounds, *AMIDES, *FLUORINATION, *AMINO acids, *CHEMICAL synthesis, *PHENOL oxidase, *CHEMICAL scavengers
Abstract

Highlights: [•] Eight N-hydroxycinnamoylamides of fluorinated amino acids have been synthesized, among them five are new. [•] We evaluated their antioxidative activities by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging test. [•] Among the tested amides, N-sinapoyl-3-fluorotyrosine methyl ester (5) exhibited the highest radical-scavenging activity. [•] SA-Trp(6-F)-OMe (4) inhibited the most significantly the formation of dopachrome in anti-tyrosinase assay. [ABSTRACT FROM AUTHOR]

Published
2013
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