This special issue of the Journal of Financial Services Research includes a selection of papers originally presented at the Tenth Annual FDIC-JFSR Fall Banking Research Conference in October 2010. The papers in this special issue were invited by the editors of the JFSR but were subjected to the regular JFSR referee process. We also invited the conference paper discussants to draft their comments for publication in this special issue. In the first article of this special issue, “Deja Vu All Over Again: The Causes of U.S. Commercial Bank Failures This Time Around,” Cole and White (2012) use a logistic regression framework to identify factors associated with more than 300 bank failures since 2009. This paper was presented in the “Reflections of the Financial Crisis” session of the Conference. The authors find that many failing banks tended to have loan exposures to real estate construction and development, commercial real estate and multifamily residential mortgages. Unlike many of the largest banks that were negatively impacted by their exposures to wholesale subprime mortgage securitization activities, residential mortgage exposures in smaller community banks tended to reduce the probability that these banks failed. The discussant for the session was Pete Kyle and his discussion underscores the importance of capital especially for small banks. Kyle (2012) also differentiates short-term and long-term effects of capital where capital is more important in the short-term but volatility of asset returns dominates in the long term. For large banks the prescription is heightened supervision, which should be geared toward understanding new risky business lines, especially those that may pose systemic risk. Three of the papers in this special issue, presented in the “Measuring Systemic Risk” session of the program, focus on the measurement of systemic risk. Robert DeYoung provides a unified discussion of systemic risk and the contributions made by each of these papers. As DeYoung (2012) points out, the profession has yet to decide on a single focused J Financ Serv Res (2012) 42:1–3 DOI 10.1007/s10693-012-0143-1