1. Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4.
- Author
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Mikhak Z, Strassner JP, and Luster AD
- Subjects
- Administration, Inhalation, Animals, Antigens administration & dosage, Antigens immunology, Apoptosis immunology, Cell Proliferation, Dendritic Cells immunology, Homeostasis immunology, Humans, Influenza, Human immunology, Influenza, Human pathology, Influenza, Human prevention & control, Lymphocyte Activation immunology, Male, Mice, Mice, Inbred C57BL, Organ Specificity immunology, Orthomyxoviridae Infections immunology, Orthomyxoviridae Infections pathology, Orthomyxoviridae Infections prevention & control, T-Lymphocytes pathology, Cell Movement immunology, Dendritic Cells pathology, Immunity immunology, Lung immunology, Lung pathology, Receptors, CCR4 metabolism, T-Lymphocytes immunology
- Abstract
T cell trafficking into the lung is critical for lung immunity, but the mechanisms that mediate T cell lung homing are not well understood. Here, we show that lung dendritic cells (DCs) imprint T cell lung homing, as lung DC-activated T cells traffic more efficiently into the lung in response to inhaled antigen and at homeostasis compared with T cells activated by DCs from other tissues. Consequently, lung DC-imprinted T cells protect against influenza more effectively than do gut and skin DC-imprinted T cells. Lung DCs imprint the expression of CCR4 on T cells, and CCR4 contributes to T cell lung imprinting. Lung DC-activated, CCR4-deficient T cells fail to traffic into the lung as efficiently and to protect against influenza as effectively as lung DC-activated, CCR4-sufficient T cells. Thus, lung DCs imprint T cell lung homing and promote lung immunity in part through CCR4.
- Published
- 2013
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