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4 results on '"Lopes, Patricia"'

2. A selfish genetic element linked to increased lifespan impacts metabolism in female house mice

Author

Lopes, Patricia C, Lindholm, Anna K, University of Zurich, and Lopes, Patricia C

Subjects
Male, 0106 biological sciences, Litter (animal), 1109 Insect Science, Evolution, Physiology, Offspring, 030310 physiology, Longevity, Aquatic Science, Biology, 010603 evolutionary biology, 01 natural sciences, Mice, 10127 Institute of Evolutionary Biology and Environmental Studies, 03 medical and health sciences, Sex Factors, Behavior and Systematics, Genotype, 1312 Molecular Biology, Animals, Allele, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Repetitive Sequences, Nucleic Acid, Genetics, 0303 health sciences, 1104 Aquatic Science, Ecology, Haplotype, 1314 Physiology, Gene drive, 1105 Ecology, Evolution, Behavior and Systematics, Meiotic drive, Haplotypes, Insect Science, 570 Life sciences, biology, 590 Animals (Zoology), Female, Animal Science and Zoology, Basal Metabolism, House mice, 1103 Animal Science and Zoology
Abstract

Gene drive systems can lead to the evolution of traits that further enhance the transmission of the driving element. In gene drive, one allele is transmitted to offspring at a higher frequency than the homologous allele. This has a range of consequences, which generally include a reduction in fitness of the carrier of the driving allele, making such systems “selfish”. The t haplotype is one such driver, found in house mice. It is linked to a reduction in litter size in matings among heterozygous animals, but also to increased lifespan in wild females that carry it. Here, we tested whether carrying the t haplotype was associated with altered resting metabolic rate (RMR). We show that females carrying the t haplotype decrease RMR as they increase in size, compared to wildtype females or males of either genotype. Our study elucidates a plausible mechanism by which a selfish genetic element increases lifespan.

Published
2019

4. A selfish genetic element linked to increased lifespan impacts metabolism in female house mice.

Author

Lopes PC and Lindholm AK

Subjects
Animals, Female, Male, Mice genetics, Sex Factors, Basal Metabolism, Haplotypes physiology, Longevity genetics, Mice physiology, Repetitive Sequences, Nucleic Acid physiology
Abstract

Gene drive systems can lead to the evolution of traits that further enhance the transmission of the driving element. In gene drive, one allele is transmitted to offspring at a higher frequency than the homologous allele. This has a range of consequences, which generally include a reduction in fitness of the carrier of the driving allele, making such systems 'selfish'. The t haplotype is one such driver, found in house mice. It is linked to a reduction in litter size in matings among heterozygous animals, but also to increased lifespan in wild females that carry it. Here, we tested whether carrying the t haplotype was associated with altered resting metabolic rate (RMR). We show that females carrying the t haplotype decrease RMR as they increase in size, compared with wild-type females or males of either genotype. Our study elucidates a plausible mechanism by which a selfish genetic element increases lifespan., Competing Interests: Competing interestsThe authors declare no competing or financial interests., (© 2020. Published by The Company of Biologists Ltd.)

Published
2020
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