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Start Over Author "Santin, José Roberto" Journal journal of ethnopharmacology
12 results on '"Santin, José Roberto"'

1. Extract of Tagetes erecta L., a medicinal plant rich in lutein, promotes gastric healing and reduces ulcer recurrence in rodents

Author

Meurer, Mariane, primary, de Oliveira, Beatriz M.M., additional, Cury, Benhur J., additional, Jerônimo, Daniele T., additional, Venzon, Larissa, additional, França, Tauani C.S., additional, Mariott, Marihá, additional, Silva-Nunes, Ruan, additional, Santos, Ana C., additional, Roman-Junior, Walter A., additional, Oliveira, Ruberlei G., additional, Arunachalam, Karuppusamy, additional, Santin, José Roberto, additional, Benvenutti, Larissa, additional, Souza, Priscila, additional, Aldana-Mejía, Jennyfer A., additional, and da Silva, Luisa, additional

Published
2022
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2. Sambucus nigra: A traditional medicine effective in reducing inflammation in mice

Author

Santin, José Roberto, primary, Benvenutti, Larissa, additional, Broering, Milena Fronza, additional, Nunes, Roberta, additional, Goldoni, Fernanda Capitanio, additional, Patel, Yasmin Beatrisse Klein, additional, de Souza, Jade André, additional, Kopp, Mainara Adriane Tesser, additional, de Souza, Priscila, additional, da Silva, Rita de Cássia Vilhena, additional, Pastor, Maria Verônica Dávila, additional, de Souza, Angelita Boldieri, additional, Testoni, Letícia Debatin, additional, Couto, Angélica Garcia, additional, Bresolin, Tania Mari Belle, additional, and Quintão, Nara Lins Meira, additional

Published
2022
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3. Toxicological and anti-inflammatory profile of Synadenium grantii Hook. f. in mice

Author

de Souza, Jade André, primary, Patel, Yasmin Beatrisse Klein, additional, Grockoski, Heloise Adeli, additional, Nunes, Roberta, additional, Ramos, Silvia Aparecida, additional, Pastor, Maria Verônica Dávila, additional, Stoeberl, Luis Carlos, additional, Campos, Adriana, additional, Cechinel Filho, Valdir, additional, Santin, José Roberto, additional, and Quintão, Nara Lins Meira, additional

Published
2021
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4. Effects of passion fruit peel flour (Passiflora edulis f. flavicarpa O. Deg.) in cafeteria diet-induced metabolic disorders

Author

De Faveri, Aline, primary, De Faveri, Renata, additional, Broering, Milena Fronza, additional, Bousfield, Izabel Terranova, additional, Goss, Marina Jagielski, additional, Muller, Samuel Paulo, additional, Pereira, Raquel Oliveira, additional, de Oliveira e Silva, Ana Mara, additional, Machado, Isabel Daufenback, additional, Quintão, Nara Lins Meira, additional, and Santin, José Roberto, additional

Published
2020
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5. Protective effects of flavonoid composition rich P. subpeltata Ortega. on indomethacin induced experimental ulcerative colitis in rat models of inflammatory bowel diseases

Author

Shanmugam, Saravanan, primary, Thangaraj, Parimelazhagan, additional, dos Santos Lima, Bruno, additional, Trindade, Gabriela G.G., additional, Narain, Narendra, additional, Mara de Oliveira e Silva, Ana, additional, Santin, José Roberto, additional, Broering, Milena Fronza, additional, Serafini, Mairim Russo, additional, Quintans-Júnior, Lucindo José, additional, and Antunes de Souza Araújo, Adriano, additional

Published
2020
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6. Effects of Eugenia umbelliflora O. Berg (Myrtaceae)-leaf extract on inflammation and hypersensitivity

Author

Goldoni, Fernanda Capitânio, primary, Barretta, Claiza, additional, Nunes, Roberta, additional, Broering, Milena Fronza, additional, De Faveri, Renata, additional, Molleri, Heloisa Tachini, additional, Corrêa, Thiago Patrício, additional, Farias, Ingrid Vicente, additional, Amorin, Clarissa Krieger, additional, Pastor, Maria Veronica Davila, additional, Meyre-Silva, Christiane, additional, Bresolin, Tania Mari Belle, additional, de Freitas, Rilton Alves, additional, Quintão, Nara Lins Meira, additional, and Santin, José Roberto, additional

Published
2019
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9. Evidence of gastric ulcer healing activity of Maytenus robusta Reissek: In vitro and in vivo studies

Author

Mota da Silva, Luisa, primary, Boeing, Thaise, additional, Somensi, Lincon Bordignon, additional, Cury, Benhur Judah, additional, Bispo Steimbach, Viviane Miranda, additional, Oliveira Silveria, Alessandro Conrado de, additional, Niero, Rivaldo, additional, Cechinel Filho, Valdir, additional, Santin, José Roberto, additional, and de Andrade, Sérgio Faloni, additional

Published
2015
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12. Tagetes erecta L.: A traditional medicine effective in inflammatory process treatment.

Author

Vaz, Carlos Rafael, Benvenutti, Larissa, Goldoni, Fernanda Capitânio, Nunes, Roberta, Schneiker, Gustavo Santin, Rosa, Gabriel Antunes, Furtado, Keyla, Garcia, Louise, Quintão, Nara Lins Meira, and Santin, José Roberto

Subjects
*ANTI-inflammatory agents, *IN vitro studies, *FLOW cytometry, *TRADITIONAL medicine, *MACROPHAGES, *NITRIC oxide, *NEUTROPHILS, *ENZYME-linked immunosorbent assay, *CELL adhesion molecules, *CELL physiology, *FLOWERS, *PLANT extracts, *MICE, *MEDICINAL plants, *ANIMAL experimentation, *INFLAMMATION, *CYTOKINES, *TUMOR necrosis factors, *PHAGOCYTOSIS, *INTERLEUKINS
Abstract

Tagetes erecta L. (Asteraceae), popularly known as Aztec Marigold, is used in folk medicine to treat several ailments including inflammatory processes. Despite its historical use, the specific mechanisms through which it may modulate inflammation, particularly its effects on neutrophils and macrophages activation, have not yet been completely investigated. This study aimed to elucidate the anti-inflammatory mechanism of the hydroalcoholic extract obtained from T. erecta flowers, focusing on its role in the regulation of neutrophil and macrophage functions. The production of TNF, IL-6, CXCL-1, IL-1β, IL-10 (ELISA) and NO (Griess reaction), adhesion molecule expression (CD62L, CD49d and CD18, flow cytometry), and chemotaxis were analyzed in vitro using oyster glycogen-recruited peritoneal neutrophils or macrophages (RAW 264.7) stimulated with lipopolysaccharide (LPS) and treated with the extract (1, 10 or 100 μg/mL). The resolution of inflammation was accessed by efferocytosis assay. The in vivo anti-inflammatory activity was investigated using carrageenan-induced inflammation in the subcutaneous tissue of male Swiss mice orally treated with the T. erecta extract (30, 100 or 300 mg/kg). The leukocyte influx (optical microscopy), secretion of chemical mediators (TNF, IL-6 and IL-1β, ELISA) and protein exudation (Bradford reaction) were quantified in the inflamed exudate. In vitro studies demonstrated that the extract inhibited neutrophil chemotaxis and reduced the production and/or release of cytokines (TNF, IL-1β, CXCL1, and IL-6) as well as nitric oxide (NO) by neutrophils and macrophages when stimulated with LPS. Neutrophils treated with LPS and incubated with the extract showed an increase in CD62L expression, which leads to the impairment of neutrophil adhesion. The extract also enhanced efferocytosis of apoptotic neutrophils by macrophages, which was accompanied by increased IL-10 secretion and decreased TNF levels. In vivo studies yielded similar results, showing reduction in neutrophil migration, protein exudation, and cytokine release (TNF, IL-6, and IL-1β). Together, the data herein obtained shows that T. erecta flower extract has anti-inflammatory effects by regulating inflammatory mediators, limiting neutrophil migration, and promoting efferocytosis. The in vivo results suggest that an herbal medicine made with T. erecta could represent an interesting pharmacological tool for the treatment of acute inflammatory condition. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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