Search

Ethnopharmacological Relevance: Mauritania is a country in which few ethnobotanical studies have been conducted and consequently the ethnomedical data is scarce. Since the geographical region reflects the transition between tropical and Northern Africa, influenced by the Mediterranean floristic region, the traditional knowledge was influenced by several cultures from tropical Africa as well as Arab, Berber and Islamic societies., Aim of the Study: This paper aims to explore and compile the diversity of ethnomedical knowledge in one of the regions of Mauritania and to compare the data with similar studies from surrounding territories., Materials and Methods: Surveys and interviews were carried out in 11 villages of Adrar province in northern Mauritania. Data were collected through open, semi-structured interviews (with individuals and focus groups). A sample of 120 people aged between 20 and 70 years, including 24 herbalists and 28 traditional healers was included., Results: Ethnomedical data for 68 plant species belonging to 27 families were obtained. They are used to treat 50 health conditions grouped in 14 pathological groups. Remedies for digestive system disorders, skin problems and respiratory ailments were among the most frequent indications. Leaves were the most frequently used plant part and remedies generally used as a powder for the various applications and a total of 2'317 use reports were gathered. About 55% of the reported species were not cited previously in the literature focusing on Mauritania and neighbouring countries. Moreover, only 6 species are also cited by Ibn al-Baytar (13th century CE)., Conclusions: This work shows a promising perspective for future studies, shedding light on the richness and the risk for conservation of traditional knowledge of herbal medicine in Mauritania., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Ethnopharmacological Relevance: Transmission of traditional knowledge over time and across culturally and historically related territories is an important topic in ethnopharmacology. Here, we contribute to this knowledge by analysing data on medicinal uses in two neighbouring areas of the Western Mediterranean in relation to a historical text that has been scarcely mentioned in historical studies despite its interest., Aim of the Study: This paper discusses the sharing of popular knowledge on the medicinal uses of plants between eastern Morocco and eastern Andalusia (Spain), focusing on one of the most useful plant families in the Mediterranean area: Lamiaceae. Moreover, we used the classical work of Ibn al-Baytar (13th century CE) The Compendium of Simple Medicaments and Foods as a basis to contrast the possible link of this information, analysing the influence of this historical text on current popular tradition of medicinal plant use in both territories., Materials and Methods: For data collection, we performed ethnobotanical field research in the eastern part of Morocco, recording current medicinal uses for the Lamiaceae. In addition, we systematically reviewed the ethnobotanical literature from eastern Andalusia, developing a database. We investigated the possible historical link of the shared uses and included in this database the information from Ibn al-Baytar's Compendium. To compare the similarity and diversity of the data, we used Jaccard's similarity index., Results: Our field work provided ethnobotanical information for 14 Lamiaceae species with 95 medicinal uses, serving to treat 13 different pathological groups. Of the total uses recorded in Morocco, 30.5% were shared by eastern Andalusia and found in Ibn al-Baytar's work. There was a higher similarity when comparing current uses of the geographically close territories of eastern Morocco and eastern Andalucía (64%) than for eastern Morocco and this historical text (43%). On the other hand, coincidences between current uses in eastern Andalusia and the ones related in the Compendium are lower, 28%., Conclusions: The coincidence of the current ethnobotanical knowledge in the two territories is high for the Lamiaceae. Probably the shared historical background, recent exchanges, information flow, and the influence of the historical herbal texts have influenced this coincidence. In this sense, there is a high plant-use overlap between Ibn al-Baytar's text and both territories: nearly half of the uses currently shared by eastern Morocco and eastern Andalusia were included in the Compendium and are related to this period of Islamic medicine, indicating a high level of preservation in the knowledge of plant usage. The study of 14 species of Lamiaceae suggests that this classical codex, which includes a high number of medicinal plants and uses, constitutes a valuable bibliographical source for comparing ancient and modern applications of plants., (Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.)

Ethnopharmacological Relevance: Plants from genus Lavandula have been used as anti-inflammatory drugs in Mediterranean traditional medicine. Nowadays, there is a growing interest for complementary medicine, including herbal remedies, to treat inflammatory bowel disease (IBD)., Aim of the Study: To test the anti-inflammatory properties of Lavandula dentata and Lavandula stoechas extracts in two inflammatory experimental models: TNBS model of rat colitis and the carrageenan-induced paw edema in mice, in order to mimic the intestinal conditions and the extra-intestinal manifestations of human IBD, respectively., Material and Methods: The extracts were characterized through the qualitative HPLC analysis. Then, they were assayed in vitro and in vivo. In vitro studies were performed in BMDMs and CMT-93 epithelial cells with different concentrations of the extracts (ranging from 0.1 to 100µg/ml). The extracts were tested in vivo in the TNBS model of rat colitis (10 and 25mg/kg) and in the carrageenan-induced paw edema in mice (10, 25 and 100mg/kg)., Results: L. dentata and L. stoechas extracts displayed immunomodulatory properties in vitro down-regulating different mediators of inflammation like cytokines and nitric oxide. They also showed anti-inflammatory effects in the TNBS model of colitis as evidenced by reduced myeloperoxidase activity and increased total glutathione content, indicating a decrease of neutrophil infiltration and an improvement of the oxidative state. Besides, both extracts modulated the expression of pro-inflammatory cytokines and chemokines, and ameliorated the altered epithelial barrier function. They also displayed anti-inflammatory effects in the carrageenan-induced paw edema in mice, since a significant reduction of the paw thickness was observed. This was associated with a down-regulation of the expression of different inducible enzymes like MMP-9, iNOS and COX-2 and pro-inflammatory cytokines, all involved in the maintenance of the inflammatory condition., Conclusion: L. dentata and L. stoechas extracts showed intestinal anti-inflammatory effect, confirming their potential use as herbal remedies in gastrointestinal disorders. In addition, their anti-inflammatory effect was also observed in other locations, thus suggesting a possible use for the treatment of the extra-intestinal symptoms of IBD., (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)

Ethnopharmacological Relevance: Different species from genus Phlomis, frequently native from the the eastern Mediterranean zone, have been used in traditional medicine as an anti-inflammatory remedy. Among other constituents, they contain polyphenols that show antioxidant properties, which are interesting for the treatment of inflammatory pathologies associated with oxidative stress in humans, such as inflammatory bowel disease (IBD). The aim of this study was to evaluate the intestinal anti-inflammatoy effect of hydroalcoholic extracts of Phlomis lychnitis and P. purpurea in the trinitrobenzenesulphonic acid (TNBS) model of rat colitis, a well characterized experimental model with some resemblance to human IBD., Materials and Methods: Hydroalcoholic extracts of both plants were characterized by determining their polyphenolic content and then assayed in the TNBS model of rat colitis. For this purpose, female Wistar rats were assigned to seven groups (n=10): healthy control, untreated TNBS-colitis and five TNBS- colitis groups treated with Phlomis lychnitis (10 and 20mg/kg), P. purpurea (10 and 25mg/kg) and sulphasalazine (200mg/kg), as a positive control. Treatments started the same day of TNBS colitis induction, and rats were sacrificed one week later. Colonic inflammation was evaluated both histologically and biochemically., Results: The histological (macroscopic and microscopic) analysis of colonic samples revealed that both extracts showed an anti-inflammatory effect, which was confirmed biochemically by a decreased colonic MPO activity, a maker of neutrophil infiltration, an increased colonic glutathione content, which counteracts the oxidative status associated with the inflammatory process, and a down-regulated iNOS expression. However, only the extract of P. purpurea reduced the expression of the proinflammatory cytokines IL-1β and IL-17, the chemokines CINC-1 and MCP-1, as well as the adhesion molecule ICAM-1, ameliorating the altered immune response associated with the colonic inflammation. Furthermore, both P. lychnitis and P. purpurea extracts were able to significantly increase the expression of markers of epithelial integrity such as MUC-2, MUC-3 and villin, thus revealing an improvement in the altered colonic permeability that characterizes colonic inflammation., Conclusions: Both extracts showed intestinal anti-inflammatory activity in the TNBS model of rat colitis, thus confirming their traditional use in digestive inflammatory complaints. In addition to their antioxidant properties, other mechanisms can contribute to this beneficial effect, like an improvement in the intestine epithelial barrier and a downregulation of the immune response., (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)

Ethnopharmacological Relevance: This paper constitutes an important contribution to the knowledge of biological resources used in ethnoveterinary practices (EVPs) in southern Europe, a territory with a clear lack of information on the subject., Aim of the Study: To catalogue, analyze, and disseminate the knowledge of plant and animal use in ethnoveterinary practices in the province of Granada. Data have been analyzed to highlight the similarities between ethnoveterinary practices and human ethnopharmacology for the same study area., Methodology: Information was gathered through open and semi-structured interviews with local people, mainly elderly shepherds and farmers, in the western part of the province. The primary data have been supplemented with information on EVPs from previous ethnobotanical works for the province. Data were gathered using the same field methods., Results: A total of 88 ethnoveterinary uses are documented for the treatment of 24 animal conditions. Of these, 82 uses involve 60 different plant species. Over three-quarters of these plants are also used for some human conditions in the same study area. Moreover, 6 animal species were catalogued for 6 other ethnoveterinary uses; four of these species were also used for similar conditions in humans. Ritual and health-prevention practices are also discussed., Conclusions: EVPs in southern Spain involve a high number of species and conditions and are strongly linked to folk tradition (i.e. how local people understand certain conditions and their treatment, sometimes in a ritual manner). Unfortunately, some evidence of their slow disappearance has been found., (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)