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Your search keyword '"Lee, Kwang Ho"' showing total 18 results
Start Over Author "Lee, Kwang Ho" Journal journal of ethnopharmacology
18 results on '"Lee, Kwang Ho"'

9. Anti-inflammatory effect of Impatiens textori Miq. extract via inhibition of NLRP3 inflammasome activation in in vitro and in vivo experimental models

Author

Sun, Xiao, primary, Shim, Do-Wan, additional, Han, Ji-Won, additional, Shin, Woo-Young, additional, Sim, Eun-Jeong, additional, Kim, Myong-Ki, additional, Heo, Kang-Hyuck, additional, Kim, Young-Kyu, additional, Koppula, Sushruta, additional, Kim, Tack-Joong, additional, Kang, Tae-Bong, additional, and Lee, Kwang-Ho, additional

Published
2015
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12. Acorus gramineus inhibits microglia mediated neuroinflammation and prevents neurotoxicity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease

Author

Jiang, Jun, primary, Kim, Jae-Jin, additional, Kim, Dong-Young, additional, Kim, Myong-Ki, additional, Oh, Na-Hyun, additional, Koppula, Sushruta, additional, Park, Pyo-Jam, additional, Choi, Dong-Kug, additional, Shin, Yong-Kook, additional, Kim, Ick-Hee, additional, Kang, Tae-Bong, additional, and Lee, Kwang-Ho, additional

Published
2012
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13. Inhibitory effects of Acorus calamus extracts on mast cell-dependent anaphylactic reactions using mast cell and mouse model

Author

Kim, Dong-Young, primary, Lee, Seung-Hwan, additional, Kim, Wan-Jae, additional, Jiang, Jun, additional, Kim, Myong-Ki, additional, Shin, Yong-Kook, additional, Kim, Dong-Woo, additional, Moon, Won-Kook, additional, Kwon, Sang-Chul, additional, Koppula, Sushruta, additional, Kang, Tae-Bong, additional, and Lee, Kwang-Ho, additional

Published
2012
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14. Anti-inflammatory and anti-allergic effects of Agrimonia pilosa Ledeb extract on murine cell lines and OVA-induced airway inflammation

Author

Kim, Jae-Jin, primary, Jiang, Jun, additional, Shim, Do-Wan, additional, Kwon, Sang-Chul, additional, Kim, Tack-Joong, additional, Ye, Sang-Kyu, additional, Kim, Myong-Ki, additional, Shin, Yong-Kook, additional, Koppula, Sushruta, additional, Kang, Tae-Bong, additional, Choi, Dong-Kug, additional, and Lee, Kwang-Ho, additional

Published
2012
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17. Protective effects of Gastrodia elata Blume on MPP+-induced cytotoxicity in human dopaminergic SH-SY5Y cells

Author

An, Hua, Kim, In Su, Koppula, Sushruta, Kim, Byung Wook, Park, Pyo Jam, Lim, Beong Ou, Choi, Wahn Soo, Lee, Kwang Ho, and Choi, Dong Kug

Subjects
*MEDICAL botany, *PARKINSON'S disease, *NEURODEGENERATION, *REACTIVE oxygen species, *ALTERNATIVE medicine, *APOPTOSIS, *ASIAN medicine, *NEUROPROTECTIVE agents, *PHARMACODYNAMICS, *PREVENTION
Abstract

Aim of the study: Gastrodia elata (GE) Blume (Orchidaceae) has been traditionally used as a folk medicine in Oriental countries since centuries for their variety of therapeutic benefits. This study is an attempt to investigate the protective effects of GE extract against MPP+-induced cytotoxicity in human dopaminergic SH-SY5Y cells and explore the neuroprotective mechanisms involved. Materials and methods: Human dopaminergic SH-SY5Y cells were used to demonstrate the protective effects of GE against multiple parameters such as MPP+-induced cell viability, oxidative damage, expression of Bcl-2 and Bax, caspase-3 and poly(ADP-ribose) polymerase proteolysis. Results: GE effectively attenuated the cytotoxicity and improved cell viability in a dose-dependent manner. GE was effective in inhibiting both, the increased production of reactive oxygen species (ROS) and increase in Bax/Bcl-2 ratio, cleaved caspase-3 and PARP proteolysis. Conclusion: Data from this study suggests the protective effects of GE on MPP+-induced cytotoxicity in dopaminergic cells, which may be ascribed to its significant anti-oxidative and anti-apoptotic properties, thus, GE might prove to be a valuable therapeutic agent for the treatment of various neurodegenerative diseases including progressive Parkinson''s disease (PD). [Copyright &y& Elsevier]

Published
2010
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18. Chrysanthemum morifolium Ramat (CM) extract protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity

Author

Kim, In Su, Koppula, Sushruta, Park, Pyo-Jam, Kim, Ee Hwa, Kim, Chan Gil, Choi, Wahn Soo, Lee, Kwang Ho, and Choi, Dong-Kug

Subjects
*CHRYSANTHEMUMS, *PLANT extracts, *NEUROBLASTOMA, *CELL-mediated cytotoxicity, *TRADITIONAL medicine, *ETHNOPHARMACOLOGY, *PARKINSON'S disease treatment, *NEUROPROTECTIVE agents
Abstract

Abstract: Ethnopharmacological relevance: Chrysanthemum morifolium Ramat (Asteraceae) has (CM) long been used in Korean and Chinese traditional herbal medicines with numerous therapeutic applications. Aim of the study: To evaluate the neuroprotective activities of Chrysanthemum morifolium (CM) extract against 1-methyl-4-phenylpridinium ions (MPP+), Parkinsonian toxin through oxidative stress and impaired energy metabolism, in human SH-SY5Y neuroblastoma cells and the underlying mechanisms. Materials and methods: The effects of CM against MPP+-induced cytotoxicity and neuronal cell viability, oxidative damage, the expression of Bcl-2 and Bax, caspase-3 and poly(ADP-ribose) polymerase (PARP) proteolysis were evaluated by using SH-SY5Y neuroblastoma cells. Results: CM effectively inhibited the cytotoxicity and improved cell viability. CM also attenuated the elevation of reactive oxygen species (ROS) level, increase in Bax/Bcl-2 ratio, cleavage of caspase-3 and PARP proteolysis. Conclusion: These results demonstrate that CM possesses potent neuroprotective activity and therefore, might be a potential candidate in neurodegenerative diseases such as Parkinson''s disease. [Copyright &y& Elsevier]

Published
2009
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