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Your search keyword '"Larcher, Gérald"' showing total 4 results
Start Over Author "Larcher, Gérald" Journal journal of enzyme inhibition and medicinal chemistry
4 results on '"Larcher, Gérald"'

4. Synthesis of new 1-[2-Azido-2-(2,4-dichlorophenyl)ethyl]-1H/-imidazoles and in vitro evaluation of their antifungal activity.

Author

Chevreuil F, Landreau A, Seraphin D, Larcher G, Bouchara JP, and Richomme P

Subjects
Alcohols, Antifungal Agents pharmacology, Aspergillus fumigatus drug effects, Azides, Candida albicans drug effects, Candida glabrata drug effects, Imidazoles chemical synthesis, Structure-Activity Relationship, Antifungal Agents chemical synthesis, Imidazoles pharmacology
Abstract

New 1-[2-azido-2-(2,4-dichlorophenyl)ethyl]-1H/-imidazole were synthesized by nucleophilic substitution of various tertiary alcohols with azide anion in presence of boron trifluoride-diethyl etherate. Their antifungal activity was evaluated against Candida albicans, Candida glabrata, Aspergillus fumigatus and an azole-resistant petite mutant of C. glabrata. Preliminary SAR results are discussed.

Published
2008
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