1. Medicinal significance of benzothiazole scaffold: an insight view
- Author
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Dharam Pal Pathak, Archana Sharma, Harish Rajak, Prabodh Chander Sharma, and Alka Sinhmar
- Subjects
Pharmacology ,Molecular Structure ,Antitubercular Agents ,Antineoplastic Agents ,General Medicine ,Antimicrobial ,Ring (chemistry) ,Antimalarials ,chemistry.chemical_compound ,Anti-Infective Agents ,Benzothiazole ,chemistry ,Drug Discovery ,Humans ,Organic chemistry ,Benzothiazoles ,Enzyme Inhibitors ,Thiazole ,Heterocyclic derivatives - Abstract
Heterocycles bearing nitrogen, sulphur and thiazole moieties constitute the core structure of a number of biologically interesting compounds. Benzothiazole, a group of xenobiotic compounds containing a benzene ring fused with a thiazole ring, are used worldwide for a variety of therapeutic applications. Benzothiazole and their heterocyclic derivatives represent an important class of compounds possessing a wide spectrum of biological activities. The myriad spectrum of medicinal properties associated with benzothiazole related drugs has encouraged the medicinal chemists to synthesize a large number of novel therapeutic agents. Several analogues containing benzothiazole ring system exhibit significant antitumour, antimicrobial, antidiabetic, anti-inflammatory, anticonvulsant, antiviral, antioxidant, antitubercular, antimalarial, antiasthmatic, anthelmintic, photosensitizing, diuretic, analgesic and other activities. This article is an attempt to present the research work reported in recent scientific literature on different pharmacological activities of benzothiazole compounds.
- Published
- 2012