1. The Effect of Tranexamic Acid on the Fibrinolytic System During Anaphylaxis in Rabbits; The Importance of the Fibrinolytic System During Anaphylaxis
- Author
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Kazuhiro Shimaya, Hiroyuki Sumi, Hisashi Mihara, Makoto Tanigawa, Masugi Maruyama, Masahiko Sugiki, and N Yamami
- Subjects
Prothrombin time ,medicine.medical_specialty ,biology ,medicine.diagnostic_test ,Activator (genetics) ,Chemistry ,medicine.medical_treatment ,medicine.disease ,Biochemistry ,Endocrinology ,Enzyme inhibitor ,Internal medicine ,Fibrinolysis ,Immunology ,medicine ,biology.protein ,Molecular Medicine ,Plasminogen activator ,Anaphylaxis ,Tranexamic acid ,Partial thromboplastin time ,medicine.drug - Abstract
We previously reported (Shimaya et al. (1992) Enzyme, 46, 204) that a rapid and strong increase of plasminogen activator (PA) was induced during anaphylaxis, and that the main plasma fibrinolytic enzyme which increased in the anaphylaxis group was shown to be tissue-type plasminogen activator (t-PA). Anaphylaxis was induced in rabbits by giving BSA after t-AMCHA injection. 44% of those rabbits died within 3 h after BSA injection. In the dead group, the euglobulin fibrinolytic activity (EFA) could not be detected by the plasminogen-rich fibrin plate method and the t-PA activity, using the natural substrate plasminogen, did not rise significantly reaching a peak at 10–15 min. However, the EFA and t-PA activity increased significantly in the surviving group. A significant prolongation of the activated partial thromboplastin time (AFTT) and the prothrombin time (PT) was observed during anaphylaxis in both groups. These findings suggest that increased PA activity during anaphylaxis is an important defe...
- Published
- 1993
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