1. Effects of ERβ and ERα on OVX-induced changes in adiposity and insulin resistance
- Author
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Aaron P. Frank, Deborah J. Clegg, Jill A. Kanaley, Jaume Padilla, Terese M. Zidon, Olivia E. Stricklin, Victoria J. Vieira-Potter, Leighton T. McCabe, Kevin L. Fritsche, Rebecca J. Welly, Young-Min Park, and Dennis B. Lubahn
- Subjects
Leptin ,0301 basic medicine ,medicine.medical_specialty ,Adipose Tissue, White ,Ovariectomy ,Endocrinology, Diabetes and Metabolism ,Gene Expression ,Estrogen receptor ,Adipose tissue ,030209 endocrinology & metabolism ,Carbohydrate metabolism ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Endocrinology ,Insulin resistance ,Adipocyte ,Internal medicine ,Animals ,Estrogen Receptor beta ,Humans ,Medicine ,Adiposity ,Mice, Knockout ,business.industry ,Estrogen Receptor alpha ,medicine.disease ,Mice, Inbred C57BL ,030104 developmental biology ,chemistry ,Body Composition ,Ovariectomized rat ,Female ,Adiponectin ,Insulin Resistance ,Energy Metabolism ,business ,Estrogen receptor alpha ,Signal Transduction ,Hormone - Abstract
Loss of ovarian hormones leads to increased adiposity and insulin resistance (IR), increasing the risk for cardiovascular and metabolic diseases. The purpose of this study was to investigate whether the molecular mechanism behind the adverse systemic and adipose tissue-specific metabolic effects of ovariectomy requires loss of signaling through estrogen receptor alpha (ERα) or estrogen receptor β (ERβ). We examined ovariectomized (OVX) and ovary-intactwild-type (WT), ERα-null (αKO), and ERβ-null (βKO) female mice (age ~49 weeks; n = 7–12/group). All mice were fed a phytoestrogen-free diet (P P
- Published
- 2020