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Tywanek Ewa, Trojanowska Paulina, Woźniak Magdalena, Wronecki Jakub, Zwolak Agnieszka, Łuczyk Robert Jan. Causes of hypoglycemia. Journal of Education, Health and Sport. 2019;9(9):905-911. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3460625 http://ojs.ukw.edu.pl/index.php/johs/article/view/7514 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 25.08.2019. Revised: 31.08.2019. Accepted: 22.09.2019. Causes of hypoglycemia Ewa Tywanek1, Paulina Trojanowska2, Magdalena Woźniak3, Jabkub Wronecki4, Agnieszka Zwolak1, Robert Jan Łuczyk1 1Chair of Internal Medicine and Department of Internal Medicine in Nursing, Medical University of Lublin, Chodźki 7, 20-093 Lublin, Poland 2Department of Pediatric Neurology, Medical University of Lublin, A. Gębali 6, 20-093 Lublin, Poland 3Chair and Department of Endocrinology, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, Poland 4Chair and Department of Gastroenterology, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, Poland; ABSTRACT: Introduction: Hypoglycemia is metabolic state of ogranism characterized by abnormally low blood glucose level. Due to International Hypoglycemia Study Group (2017) and following Polish Diabetes Association Guidelines is recognized with serum glucose below 70mg/dl – with or without accompanying symptoms, such as tremor or altered mental status or even hypoglycemic coma. Symptoms mentioned above may have huge impact on personal or social functioning of the patient. Purpose: To present a list of known causes of hypoglycemic state. Summary: Hypoglycemia is quite unpleasant and dangerous metabolic state that may be caused by multiple etiological factors. The most common cause of this condition is useing too much insulin in treatment of diabetes mellitus. Other diabetic drugs, such us for example sulphonylureas may result in hypoglycemia. Chemicals containing sulfhydryl group in their structure may result in severe hypoglycemia in progress of Insulin Autoimmune Syndrome (IAS). Organic basis of hypoglycemia due to increased amount of producing insulin may be recognized, in progress of pancreatic secreting tumor, called insulinoma. From the other hand functional abnormality of carbohydrate metabolism may be found. It’s called functional hypoglycemia and may develop due to presence of hyperinsulism and insulin resistance secondary to incorrect lifestyle and diet. Partly organic and functional cause of hypogycemia may be recognized after bariatric surgery. Fairy seldom hypoglycemia with low blood insulin level may be found. The example of this state constitutes Dodge-Potter Syndrome, when tumor is able to produce insulin-growth factor 2 (IGF-2) stimulating insulin receptor, what results in serum glucose reduction. Hypoglycemia, as very adverse state for human organism, should be closely diagnose and efficiently treated. Keywords: hypoglycemia; drug-induced hypoglycemia; insulinoma; Non-Islet cell tumors hypoglycemia; Dodge-Potter Syndrome; post-bariatric hypoglycemia