Huangmeijian composite pluton is a uranium-bearing A-type granite in Middle-lower Yangtze River valley metallogenic belt. Huangmeijian composite pluton can be divided into four emplacement stages from earliest to latest, including stage Ⅰ biotite quartz syenite, stage Ⅱ syenite porphyry, stage Ⅲ quartz syenite and stage Ⅳ alkali feldspar granite. The vein-type uranium mineralization predominantly occurs along the contacts between the stage Ⅰ biotite quartz syenite and the clastic rocks. The study on the micro-textures, REE characteristics and U-Pb dating of zircons in Huangmeijian composite pluton was carried out. The results show that the zircons of biotite quartz syenite, syenite porphyry and quartz syenite are of magmatic genesis, and yield zircon U-Pb ages of(131.8±1.1),(129.7±1.6),(124.7±1.6)Ma, respectively. The cores of zircons in alkali feldspar granite are of magmatic genesis and undergo metamictization, while the rims of zircons in alkali feldspar granite are altered by hydrothermal fluid, and probably undergo recrystallization. The zircon U-Pb dating of alkali feldspar granite yields the crystallization age of(111.5±1.3)Ma and the hydrothermal activity age of(107.6±2.1)Ma. Based on the previous geochronological studies, the A-type granites in Middle-lower Yangtze River valley metallogenic belt can be divided into three periods. The early period is represented by biotite quartz syenite and syenite porphyry with crystallization age of 132-129 Ma; the main period is represented by quartz syenite and syenogranite with crystallization age of 128-124 Ma; the late period is represented by alkali feldspar granite with crystallization age of 115-110 Ma. The crystallization ages of alkali feldspar granite and hydrothermal activity time are close to the uranium mineralization ages; combining with the stable isotope studies, it probably indicates that stage Ⅳ alkali feldspar granite of Huangmeijian composite pluton has provided the ore-forming fluid and heat for the uranium mineralization. [ABSTRACT FROM AUTHOR]