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Voluminous Early Cretaceous granitoids and associated large-scale ore deposits are distributed within the southern Great Xing' an Range (SGXR), NE China. Based on previously published geochronology and zircon Hf-isotope data, Hf isotope mapping is undertaken to improve our understanding of crustal architecture and its controls on ore deposits. The ore-related Early Cretaceous granitoids were sourced predominantly from juvenile crust, with the involvement of variable proportions of ancient crustal materials. The crustal architecture, as inferred from Hf isotopic contour maps, indicates two distinct Hf isotopic domains in SGXR, including (1) a higher-εHf (+7 to +11) juvenile crust containing minor ancient crustal material, and (2) a lower-εHf (+2 to +6) juvenile crust containing a greater proportion of ancient crustal materials. The Hf isotopic maps identify links between crustal architecture and regional metallogeny. Copper deposits and other deposits with significant Cu production are restricted mainly to the higher-εHf juvenile crustal regions in the northern and eastern SGXR. Deposits dominated by other metals (e.g., Mo, Sn, W, Pb, Zn, and Ag) occur mainly in the lower- εHf juvenile crustal regions in the southern and western SGXR. Interaction between juvenile crust-derived melts and ancient crustal components played an important role on the distribution of various ore metals. [ABSTRACT FROM AUTHOR]