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Your search keyword '"Fan, Mingliang"' showing total 4 results
Start Over Author "Fan, Mingliang" Journal journal of drug targeting
4 results on '"Fan, Mingliang"'

4. Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery.

Author

Fan, Mingliang, Liang, Xiaofei, Yang, Danbo, Pan, Xiaorong, Li, Zonghai, Wang, Hongyang, and Shi, Bizhi

Subjects
*EPIDERMAL growth factor receptors, *DOXORUBICIN, *PHOSPHOLIPIDS, *MICELLES, *TARGETED drug delivery
Abstract

Specific targeting of tumor cells to achieve higher drug levels in tumor tissue and to overcome side effects is the major goal in cancer chemotherapy. In this study, we used a tumor targeting peptide, GE11, to conjugate onto the surface of doxorubicin encapsulated phospholipid micelles. The GE11 peptide triggered specific binding to epidermal growth factor receptor (EGFR), leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation in the tumors in vivo. The results indicated that GE11 conjugated phospholipid micelles should have potential applications in cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2016
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