1. Adenosine-associated delivery systems
- Author
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Kazemzadeh-Narbat, Mehdi, Annabi, Nasim, Tamayol, Ali, Oklu, Rahmi, Ghanem, Amyl, and Khademhosseini, Ali
- Subjects
Biotechnology ,Bioengineering ,Neurosciences ,Adenosine ,Animals ,Drug Delivery Systems ,Drug Design ,Half-Life ,Humans ,Polymers ,controlled drug delivery ,controlled release ,drug delivery ,drug targeting ,nanoparticles ,targeted drug delivery ,Pharmacology and Pharmaceutical Sciences ,Pharmacology & Pharmacy - Abstract
Adenosine is a naturally occurring purine nucleoside in every cell. Many critical treatments such as modulating irregular heartbeat (arrhythmias), regulation of central nervous system (CNS) activity and inhibiting seizural episodes can be carried out using adenosine. Despite the significant potential therapeutic impact of adenosine and its derivatives, the severe side effects caused by their systemic administration have significantly limited their clinical use. In addition, due to adenosine's extremely short half-life in human blood (
- Published
- 2015