Search

The present work describes the synthesis of biocompatibe alkali-free glasses utilizing the agricultural waste rice husk and eggshells. A series of glasses with basic composition SiO2–P2O5–MgO–CaO has been synthesized using melt-quench technique, where P2O5 is partially replaced by MnO. These glasses are characterized to assess their in-vitro reactivity with the help of X-Ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, fourier transform infrared spectroscopy, and microwave plasma atomic emission spectroscopy techniques before and after soaking in the simulated body fluid solution. Further, drug loading and release studies are carried out with the help of UV–Visible spectrophotometer. Wherefore, a multivariable non-linear regression model has been developed to predict the release rate at different manganese oxide concentrations. The proposed model shows a high Pearson correlation coefficient between the observed and predicted absorbance. These results designate that low-cost agro-waste derived alkali-free glasses have potential in medical applications in drug delivery as well as it helps in environmental pollution management.

The present work reports on the synthesis and biocompatibility of SiO2–P2O5–MgO–CaO–SrO glass system. The MgO was partially replaced by the SrO to check its influence on the bioactivity of the glass samples. The silica used for the development of glass samples was obtained from rice husk ash using acid-base precipitation technique. The structural, morphological and thermal properties of the synthesized glasses are characterized by X-Ray diffraction (XRD), fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and differential thermal analysis (DTA) techniques. The bioactivity of the glasses was monitored by surface activity of the glass samples after treatment with the simulated body fluid (SBF). The evolution of the apatite layer was confirmed by observing variations in the crystal structures, morphological features, and evolution of new functional groups. The release of the ions in the SBF solution was examined by microwave plasma atomic emission spectroscopy (MP-AES). Evolution of the hydroxyapatite (HAp) layer was also examined by optical-analytic approach. Further the drug loading efficiency was measured using VANCO as model drug. The incorporation of SrO led to enhancement in the bioactivity of the glass samples as compared to the one without it.